Sökning: "IgG subclass"

Visar resultat 1 - 5 av 28 avhandlingar innehållade orden IgG subclass.

  1. 1. Clinical and immunological aspects of IgG subclass deficiency : Predictors for the need of immunoglobulin replacement therapy

    Författare :Per Wågström; Charlotte Dahle; Sofia N. Nyström; Åsa Nilsdotter-Augustinsson; Mats Nilsson; Ola Winqvist; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunoglobulin G subclass deficiency; inflammation; lymphocytes; fatigue; co-morbidity; immunoglobulin G replacement therapy;

    Sammanfattning : Background: Predominantly antibody deficiencies (PAD) are inborn errors of immunity, and associate with increased susceptibility to infections. Life-long immunoglobulin replacement therapy (IgRT) is introduced based on Ig-levels and the frequencies and severity of infections. LÄS MER

  3. 2. Regulation of IgG subclass switching in human B cells

    Författare :Qiang Pan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human IgG can be subdivided into four subclasses, each encoded by a separate heavy chain constant (CH) region gene and endowed with unique biological and functional properties. Deficiencies of single or multiple IgG subclasses have been suggested to be associated with increased susceptibility to recurrent infections in humans. LÄS MER

  4. 3. Development of IgG subclass antibodies to allergens in early childhood

    Författare :Maria C. Jenmalm; Örjan Strannegård; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Background: Immune responses to allergens in young children include both Thl and Th2 like immunity, which may regulate the secretion of IgG subclass antibodies differently. The time, route and level of exposure to an allergen, as well as maternally transferred immunity, may be decisive whether sensitisation or tolerance will ensue. LÄS MER

  5. 4. Infectious and bleeding complications in patients with hematological malignancies : Studies on diagnosis and prevention

    Författare :Tobias Svensson; Honar Cherif; Martin Höglund; Jan Sjölin; Christine Wennerås; Uppsala universitet; []
    Nyckelord :Chronic lymphocytic leukemia; Immunodeficiency; Hypogammaglobulinemia; IgG subclass; Pneumococci; Pneumococcal vaccine; Polysaccharide vaccine; Protein-conjugate vaccine; Aspergillosis; Bronchoalveolar lavage; Invasive fungal disease; Pneumocystis jirovecii pneumonia; Myelodysplastic syndrome; Azacitidine; Eltrombopag; Thrombocytopenia; Thrombopoietin receptor; Oncology; Onkologi;

    Sammanfattning : The overall aim of this thesis is to improve knowledge about the prevention of infectious and bleeding complications in patients with hematological malignancies, primarily in those with chronic lymphocytic leukemia (CLL) and myelodysplatic syndrome (MDS).Hypogammaglobulinemia, impaired production of immunoglobulins (Ig), is an established risk factor for infection, but the impact of IgG pure subclass deficiency (IgG subclass deficiency with adequate production of IgG, IgA, and IgM) has been debated. LÄS MER

  7. 5. Antibodies during pregnancy : Aspects on complications during pregnancy and complications related to transfusion

    Författare :Miodrag Palfi; Olof Sjöberg; Linköpings universitet; []
    Nyckelord :Pregnancy; Thl; Th2; hernolytic disease of the newborn; anti-D; IgG subclasses; IgG transport; post-transfusion reactions; acute lung injury; MEDICINE; MEDICIN;

    Sammanfattning : The fetus acquires half of its genetic infonnation from the father and represents a foreign graft in pregnancy. The overall mechanisms contributing to immunologic tolerance and successful pregancy still are an enigma. Accumulating results of immunologic research, however, offer an explanation for many events in pregnancy. LÄS MER