Sökning: "phosphoryl transfer"

Visar resultat 6 - 10 av 11 avhandlingar innehållade orden phosphoryl transfer.

1. 6. Studies on the Differential Specificity of Protein Kinases and Its Applications

   Författare :Mart Loog; Bengt Jergil; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Protein kinases; protein kinase inhibitors; substrate specificity; peptide libraries; affinity chromatography; Biokemi; Biochemistry; Biokemi; biokemi; Biochemistry;

   Sammanfattning : Protein kinases are enzymes that catalyse the phosphoryl transfer from the g-phosphate of ATP to acceptor amino acids in proteins. The specificity of selected model protein kinases was studied at three different levels using a) novel bi-substrate-analogue inhibitors, b) synthetic peptide substrates and c) mutated protein substrate analogues. LÄS MER

3. 7. Expanding the Amino Acid Alphabet by Design : Enhanced and Controlled Catalytic Activity in Folded Polypeptide Catalysts

   Författare :N. Johan V. Lindgren; Lars Baltzer; Harri Lönnberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chemistry; Kemi; Organic Chemistry; organisk kemi;

   Sammanfattning : This thesis addresses structure and reactivity of polypeptide catalysts in reactions that mimic the hydrolysis of RNA and DNA. A designed helix-loop-helix motif was used as a scaffold where the amino acid residues were systematically varied. LÄS MER

4. 8. Computational Protein Evolution : Modeling the Selectivity and Promiscuity of Engineered Enzymes

   Författare :Klaudia Szeler; Shina C. Lynn Kamerlin; Mikael Widersten; Maria Ramos; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; enzymes; kinetics; catalysis; density functional theory; empirical valence bond; diesters; evolution; promiscuity; Biokemi; Biochemistry;

   Sammanfattning : Enzymes are biological catalysts that significantly increase the rate of all biochemical reactions that take place within cells and are essential to maintain life. Many questions regarding their function remain unknown. LÄS MER

5. 9. Cysteine biosynthesis in Mycobacterium tuberculosis as potential drug target

   Författare :Katharina Brunner; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The bacterium Mycobacterium tuberculosis is the underlying cause of tuberculosis, one of the most devastating infectious diseases, causing 1.4 million deaths in 2015. LÄS MER

7. 10. Synthesis of Novel Homoserine Analogues - Towards t he Development of Substrate-based Peptide Inhibitors of cAMP-dependent Protein Kinase

   Författare :Anna-Carin Carlsson; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein kinases; protein kinase inhibitors; substrate-based kinase inhibitors; cAMP-dependent protein kinase; kemptide; homoserine; asymmetric -amino acid synthesis; glycine -anion equivalents; Schöllkopf’s bislactim ether; epoxidation; nucleophilic epoxide ring opening; microwave-assisted synthesis;

   Sammanfattning : Protein kinases are enzymes that via phosphorylation of proteins/peptides regulate most aspects of cell functions and physiology. The enzymes transfer a -phosphoryl group from ATP to hydroxyl groups of Ser, Thr and Tyr residues in their substrates. LÄS MER