Sökning: "p53 gene"

Visar resultat 11 - 15 av 210 avhandlingar innehållade orden p53 gene.

  1. 11. Detection and analysis of genetic alterations in normal skin and skin tumours

    Författare :Åsa Sivertsson; KTH; []
    Nyckelord :single cell; DNA sequencing; p53; mutation; UV; BCC; pyrosequencing; malignant melanoma; N-ras;

    Sammanfattning : The investigation of genetic alterations in cancer-relatedgenes is useful for research, prognostic and therapeuticpurposes. However, the genetic heterogeneity that often occursduring tumour progression can make correct analysischallenging. LÄS MER

  3. 12. Understanding the role of long non-coding RNAs in neuroblastoma development and progression

    Författare :Sanhita Mitra; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Long non-coding RNAs; NBAT1; NRSF REST; CASC15; chromosome 6p22; SOX9; USP36; CHD7; p53; CRM1; MDM2;

    Sammanfattning : Neuroblastoma (NB), a common cancer of childhood, contributes to 15% of all pediatric cancer deaths. The improper neuronal differentiation of neural crest cells to mature neurons in the sympathetic nervous system leads to NB tumor formation. LÄS MER

  4. 13. Hodgkin Lymphoma : Studies of Advanced Stages, Relapses and the Relation to Non-Hodgkin Lymphomas

    Författare :Rose-Marie Amini; Volker Diehl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Hodgkin lymphoma; advanced stages; relapse; p53; EBV; Rb; cell line; Onkologi; Oncology; Onkologi; Oncology; onkologi;

    Sammanfattning : The relationship between Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) is not entirely elucidated and a clonal relation may be present more often than previously believed. Mechanisms of tumour progression and resistance to therapy are poorly understood.Between 1974 and 1994 all individuals in Sweden with both HL and NHL were identified. LÄS MER

  5. 14. Activity and Regulation of Telomerase in Malignant Cells

    Författare :Anna Lindkvist; Ylva Paulsson-Karlsson; Göran Roos; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; apoptosis; ATC; c-Myc; drug sensitivity; ESCC; hTERT; hypoxia; IFN; MM; neuroblastoma; p53; telomerase; TGF-β; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Sammanfattning : An important step in tumorgenesis is the acquisition of cellular immortality. Tumor cells accomplish this by activating the enzyme telomerase, and thereby avoiding replicative senescence. The aim of this thesis was to study the activity and regulation of telomerase in a panel of malignant cell types. LÄS MER

  7. 15. Transcriptional Regulation of the Platelet-Derived Growth Factor beta-receptor

    Författare :Anders Hackzell; Göteborgs universitet; []
    Nyckelord :PDGF; cell cycle; p73; p53; SV40; NF-Y; Sp1; Myc;

    Sammanfattning : The Platelet Derived-Growth Factor (PDGF) receptors and ligands are expressed in cells of predominantly mesenchymal origin. Binding of the ligands to the receptors stimulates cell proliferation and other cellular responses such as differentiation and cell movement. LÄS MER