Sökning: "nucleotide sequence"

Visar resultat 1 - 5 av 183 avhandlingar innehållade orden nucleotide sequence.

1. 1. Nucleotide Substitution Patterns in Vertebrate Genomes

   Författare :Carina Farah Mugal; Hans Ellegren; Ziheng Yang; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nucleotide substitutions; mutation rate variation; strand asymmetries; CpG effect; GC-biased gene conversion; codon evolution; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

   Sammanfattning : The rates and patterns at which nucleotide substitutions occur vary significantly across the genome sequence of vertebrates. A prominent example is the difference in the rate of evolution of functional sequences versus nonfunctional (neutrally evolving) sequences, which is explained by the influence of natural selection on functional sequences. LÄS MER

3. 2. From Sequence to Sorting : Prediction of Signal Peptides

   Författare :Henrik Nielsen; Philipp Bucher; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

   Sammanfattning : In the present age of genome sequencing, a vast number of predicted genes are initially known only by their putative nucleotide sequence. The newly established field of bioinformatics is concerned with the computational prediction of structural and functional properties of genes and the proteins they encode, based on their nucleotide and amino acid sequences. LÄS MER

4. 3. Genetic Sequence Analysis by Microarray Technology

   Författare :Emilie Hultin; Joakim Lundeberg; Afshin Ahmadian; Marie Allen; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Genotyping; single nucleotide polymorphism SNP ; protease-mediated allele-specific extension PrASE ; microarray; tag-array; competitive hybridization; human papillomavirus HPV ; single cell; loss of alleles; differentiation; epidermis.; Bioengineering; Bioteknik;

   Sammanfattning : Developments within the field of genetic analysis have during the last decade become enormous. Advances in DNA sequencing technology have increased throughput from a thousand bases to over a billion bases in a day and decreased the cost thousandfold per base. LÄS MER

5. 4. Algorithms for building and evaluating multiple sequence alignments

   Författare :Timo Lassmann; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Bioinformatics; sequence analysis; sequence alignment; multiple sequence alignment;

   Sammanfattning : The alignment of biological sequences is crucial for the transfer of annotation from model organisms to humans. Pairwise alignment of sequences can reveal homology while multiple alignments are used to characterize protein families and elucidate their evolutionary history. LÄS MER

7. 5. Methods for Analysis of Disease Associated Genomic Sequence Variation

   Författare :Lovisa Lovmar; Ann-Christine Syvänen; Pui-Yan Kwok; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; microarray; molecular medicine; single nucleotide polymorphism; whole genome amplification; breast cancer; endometrial cancer; human rotavirus; Molekylärmedicin; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ;

   Sammanfattning : In Molecular Medicine a wide range of methods are applied to analyze the genome to find genetic predictors of human disease. Apart from predisposing disease, genetic variations may also serve as genetic markers in the search for factors underlying complex diseases. LÄS MER