Sökning: "strand asymmetries"

Hittade 2 avhandlingar innehållade orden strand asymmetries.

1. 1. Nucleotide Substitution Patterns in Vertebrate Genomes

   Författare :Carina Farah Mugal; Hans Ellegren; Ziheng Yang; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nucleotide substitutions; mutation rate variation; strand asymmetries; CpG effect; GC-biased gene conversion; codon evolution; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

   Sammanfattning : The rates and patterns at which nucleotide substitutions occur vary significantly across the genome sequence of vertebrates. A prominent example is the difference in the rate of evolution of functional sequences versus nonfunctional (neutrally evolving) sequences, which is explained by the influence of natural selection on functional sequences. LÄS MER

3. 2. DNA precursor asymmetries, Mismatch Repair and their effect on mutation specificity

   Författare :Robert Buckland; Andrei Chabes; Juan Méndez; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA Replication Fidelity; Mutations; dNTP pools; Mismatch Repair; Checkpoint; Ribonucleotide Reductase; Msh2; medicinsk biokemi; Medical Biochemistry; molekylärbiologi; Molecular Biology;

   Sammanfattning : In order to build any structure, a good supply of materials, accurate workers and quality control are needed. This is even the case when constructing DNA, the so-called “Code of Life.” For a species to continue to exist, this DNA code must be copied with incredibly high accuracy when each and every cell replicates. LÄS MER