Sökning: "nicotine"

Visar resultat 36 - 40 av 119 avhandlingar innehållade ordet nicotine.

  1. 36. Imaging brain functions during neuropsychological testing

    Författare :Per Hamid Ghatan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Keywords: Positron Emission Tomography; Cognition; Alcohol; Nicotine; Brain injury; Interference;

    Sammanfattning : This thesis has dealt with the development of tools for assessing cognitive functions(attention and working memory) using functional imaging and the evaluation of the modulatory effects of performance, nicotine, alcohol, brain injury and auditory interference. Two cognitive tasks commonly used in the assessment of patients with brain injury, the externally-generated Perceptual Maze Test (PMT) and an internally-generated arithmetical task, Serial-7, were used as activation paradigms. LÄS MER

  3. 37. Nicotinic effects on midbrain dopamine neurons : a dual mechanism of action

    Författare :Björn Schilström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :nicotine; dopamine; ventral tegmental area; glutamate; microdialysis; Fos expression; NMDA receptor; presynaptic;

    Sammanfattning : The neurons of the mesocorticolimbic dopamine system are located in the ventral tegmental area (VTA) in the mesencephalon and send their projections to forebrain structures, such as the prefrontal cortex, the amygdala and the nucleus accumbens. The dopamine system is important in regulating mood and motivation as well as cognitive function and appear to be primarily involved in drug dependence, since most drugs abused by man stimulate this system. LÄS MER

  4. 38. Regulation of glucose transport and insulin-stimulated GLUT4 translocation in skeletal muscle

    Författare :Jorge E Rincón Viatela; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :skeletal muscle; glucose transport; insulin resistance; hyperglycaemia; steroid hormones; smoking; nicotine;

    Sammanfattning : Skeletal muscle represents about 40% of body mass and accounts for at least 80% of glucose disposal under insulin-stimulated conditions. Furthermore, GLUT4 transport protein is the primary component of the glucose transport system in skeletal muscle. LÄS MER

  5. 39. Issues of validity in longitudinal studies of youth tobacco use

    Författare :Ann Post; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cohort; validity; smoking; smokeless tobacco; adolescents; participation; consent; retrospective reports; nicotine dependence; attrition;

    Sammanfattning : In the Stockholm region, a prospective longitudinal study: BROMS Cohort Study (Children s Smoking and Environment in the Stockholm County) was conducted between 1997 and 2005, with the primary aim to investigate determinants of adolescents´ tobacco use. It was based on a sample recruited in schools with junior high grades. LÄS MER

  7. 40. Inherited smoking behaviour and Human Epididymis Protein 4 predict smoking-related morbidity and mortality

    Författare :Sara Halldén; Kardiovaskulär forskning - hypertoni; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Smoking; nicotine dependence; GWAS; SNP; prediction; CVD; cancer; COPD; prevention; biomarkers; HE4; dyspnea;

    Sammanfattning : GENERAL AIM: To investigate prognostic markers identifying smokers with increased risk of smoking-related diseases in the population. BACKGROUND: Gene variance in the BDNF- respectively CHRNA-gene has been implicated in different smoking behaviours and the risk alleles have also demonstrated an additional risk increase of smoking-related diseases. LÄS MER