Sökning: "nicotine"

Visar resultat 31 - 35 av 119 avhandlingar innehållade ordet nicotine.

  1. 31. On the role of NMDA receptor subunits in the acute and chronic effects of nicotine

    Författare :Alexander Kosowski; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PCR; microdialysis; Wistar;

    Sammanfattning : Nicotine is considered the main dependence-producing constituent in tobacco products. In analogy with other drugs of abuse, nicotine enhances dopamine (DA) neurotransmission within the mesocorticolimbic DA system. LÄS MER

  3. 32. Cholinergic receptors in human prenetal brain : presence, distribution and influence of nicotine and ethanol

    Författare :Lena Falk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Events early in life, including exposure to various compounds, may cause disturbances in brain development. Both maternal smoking and alcohol drinking during pregnancy can induce preand postnatal death, cognitive and neurobehavioral disturbances. LÄS MER

  4. 33. The role of substance P in respiratory control in the newborn : effects of morphine and nicotine

    Författare :Jonas Berner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : We breathe in order to maintain oxygen, carbon dioxide and pH levels within the physiological range in response to the metabolic demands of the body. To achieve this, the respiratory control system is dependent on input from peripheral and/ central chemosensitive areas and on participation of different neuromodulator systems. LÄS MER

  5. 34. Importance of endogenous kynurenic acid in brainm catecholaminergic processes and in the pathophysiology of schizophrenia

    Författare :Sophie Erhardt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Schizophrenia; kynurenic acid; nicotine; VTA; dopamine; NMDA-receptors;

    Sammanfattning : Kynurenic acid is a metabolite of tryptophan and the only known naturally occurring NMethylD-Aspartic acid (NMDA)-receptor antagonist (at the co-agonist glycine site) in the human brain. The aim of the present work was to investigate the physiological and pharmacological significance of endogenous kynurenic acid as well as its putative pathophysiological implications. LÄS MER

  7. 35. Sudden infant death syndrome : a medico-legal study of related cardiovascular, toxicological and genetic findings

    Författare :Petra Råsten Almqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cardiovascular malformation; Cotinine; Heart weight; mtDNA; Myocarditis; Nicotine; SIDS;

    Sammanfattning : The present medico-legal investigation of the deaths of infants less than one year of age was designed to enhance our understanding of the Sudden Infant Death Syndrome (SIDS). Special emphasis was placed on the significance of cardiovascular pathology (including heart weight, malformations and myocarditis); exposure to nicotine; and mutations and/or polymorphisms in mitochondrial DNA (mtDNA). LÄS MER