Sökning: "HE4"

Hittade 4 avhandlingar innehållade ordet HE4.

1. 1. Clinical implementation of novel diagnostic biomarkers for epithelial ovarian cancer - Can we improve diagnosis?

   Författare :Maria Lycke; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ovarian neoplasms; EOC; Diagnosis; protein biomarkers; HE4; CA125; Algorithms; RMI; ROMA; NGS; rare mutations; liquid biopsies; screening;

   Sammanfattning : Background: Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer. The 5-year survival is about 30%, a consequence of failure to establish early diagnosis due to unspecific symptoms. LÄS MER

3. 2. Inherited smoking behaviour and Human Epididymis Protein 4 predict smoking-related morbidity and mortality

   Författare :Sara Halldén; Kardiovaskulär forskning - hypertoni; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Smoking; nicotine dependence; GWAS; SNP; prediction; CVD; cancer; COPD; prevention; biomarkers; HE4; dyspnea;

   Sammanfattning : GENERAL AIM: To investigate prognostic markers identifying smokers with increased risk of smoking-related diseases in the population. BACKGROUND: Gene variance in the BDNF- respectively CHRNA-gene has been implicated in different smoking behaviours and the risk alleles have also demonstrated an additional risk increase of smoking-related diseases. LÄS MER

4. 3. Ovarian cancer. Biomarkers, surgical outcome and survival

   Författare :Pia Leandersson; Lund Obstetrik och gynekologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epitelial äggstokscancer; biomarkörer; kirurgi; incidens; överlevnad; epithelial ovarian cancer; biomarkers; ovarian cancer surgery; incidence; survival;

   Sammanfattning : Ovarian cancer is the eighth most common female cancer worldwide and the most lethal of the gynaecologic malignancies. Around 700 women are diagnosed in Sweden per year. Due to vague symptoms most of the patients are diagnosed with late-stage epithelial ovarian cancer (EOC) and prognosis is poor, with a five-year survival of 49%. LÄS MER

5. 4. Early Diagnosis of Epithelial Ovarian Cancer - Analysis of Novel Biomarkers

   Författare :Björg Kristjansdottir; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epithelial Ovarian Cancer; Ovarian cyst fluid; Tumor biomarkers; Proteomics; Pelvic mass; Mass Spectometry; SELDI-TOF MS; iTRAQ;

   Sammanfattning : Early Diagnosis of Epithelial Ovarian Cancer - Analysis of Novel Biomarkers Björg Kristjánsdóttir Department of Obstetrics & Gynecology, Institute of Clinical Sciences at Sahlgrenska Academy, University of Gothenburg, Sweden ABSTRACT Background: Majority of epithelial ovarian cancer (EOC) is detected in advanced stage with bad prognosis and high mortality. Reliable diagnostic markers are lacking, pre-cancerous lesions in the more aggressive tumors are not clearly defined, vague or unspecific early symptoms, and the localization of the ovaries, deep in the pelvis contributes to late diagnose. LÄS MER