Sökning: "mutational analysis"

Visar resultat 21 - 25 av 116 avhandlingar innehållade orden mutational analysis.

1. 21. The mutational landscape and microenvironment in myelodysplastic syndromes with deletion of chromosome 5q

   Författare :Christian Scharenberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Myelodysplastic Syndromes (MDS) with deletion of chromosome 5q (del(5q) are malignant bone marrow disorders characterized by macrocytic anemia, chronic transfusion dependency and an increased risk of progression to acute myeloid leukemia. A high proportion of patients with lower-risk del(5q) myelodysplastic syndromes will respond to lenalidomide treatment, but more than 40% of patients have progressed to acute leukemia five years after starting treatment. LÄS MER

3. 22. Herpes simplex virus infection: epidemiological aspects and analysis of the type-specific antibody response

   Författare :Petra Tunbäck; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; herpes simplex virus; first episode genital herpes; seroepidemiology type-specific antibody-response; glycoprotein G-1; epitope-mapping;

   Sammanfattning : Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are ubiquitous viruses, often leading to asymptomatic infections in humans. However, different clinical presentations can be seen including recurrent oral or genital lesions, meningitis and neonatal herpes. LÄS MER

4. 23. Directed Evolution of Glutathione Transferases with Altered Substrate Selectivity Profiles : A Laboratory Evolution Study Shedding Light on the Multidimensional Nature of Epistasis

   Författare :Wei Zhang; Bengt Mannervik; Bengt-Harald Jonsson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; glutathione transferase; azathioprine; directed evolution; semi-rational design; catalytic mechanism; saturation mutagenesis; reduced amino acid alphabets; molecular docking; protein evolution; multivariate data analysis; epistasis; fitness landscape; evolutionary trajectories; Biochemistry; Biokemi; Biokemi; Biochemistry;

   Sammanfattning : Directed evolution is generally regarded as a useful approach in protein engineering. By subjecting members of a mutant library to the power of Darwinian evolution, desired protein properties are obtained. Numerous reports have appeared in the literature showing the success of tailoring proteins for various applications by this method. LÄS MER

5. 24. Structural and biochemical analysis of two copper proteins - plastocyanin from spinach and nitrite reductase from Rhodobacter sphaeroides 2.4.3

   Författare :Frida Jacobson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Plastocyanin; X-ray crystallography; nitrite reductase; copper geometry; redox; copper protein; photosynthesis; reduction potential; denitrification; electron transfer;

   Sammanfattning : Plastocyanin from spinach and nitrite reductase from Rhodobacter sphaeroides 2.4.3 are two copper-containing proteins that are involved in biological electron transport chains: plastocyanin operates in photosynthesis and nitrite reductase takes part in the denitrification pathway. LÄS MER

7. 25. Pancreatic Cancer. Experimental and Clinical Studies

   Författare :David Ljungman; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic neoplasms; Proteasome inhibitors; Apoptosis; Intracellular signaling peptides and proteins; Epidermal growth factor receptor; Pancreaticoduodenectomy; Cost and cost analysis; Quality-adjusted life years; Copy number variations; Comparative genomic hybridization;

   Sammanfattning : Background: Pancreatic cancer is one of the most lethal of known cancers and the only treatment with possibility of cure is surgery. The costs associated with treatment of pancreatic cancer are reputably high, both in terms of morbidity and financially. LÄS MER