Sökning: "miR-146a"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet miR-146a.

  1. 1. Functional Role of Genetic Polymorphisms Associated with Systemic Lupus Erythematosus

    Författare :Sara E Löfgren; Ulf Gyllensten; Jan Hillert; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoimmunity; systemic lupus erythematosus; genetic association; single nucleotide polymorphism; IRF5; CD226; miR-146a; Medical Science; Medicinsk vetenskap; Medical Genetics; Medicinsk genetik;

    Sammanfattning : Systemic lupus erythematosus (SLE) is a chronic and complex autoimmune disorder characterized by a failure in the mechanism of self-tolerance and production of autoantibodies, potentially affecting any organ in the body. The genetic factors behind the disease have been extensively studied in the past years and to date a list of more than 30 loci have been associated with SLE. LÄS MER

  3. 2. MicroRNAs in skin immunity and psoriasis

    Författare :Florian Meisgen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The skin protects the organism from the environment and shields it from the constant danger of infections by microorganisms. Keratinocytes are epithelial cells in the skin that constitute a physical barrier towards the environment. LÄS MER

  4. 3. Gene regulation in psoriatic keratinocytes : microRNAs and cytokine responses

    Författare :Ankit Srivastava; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Psoriasis is the most common chronic skin inflammation in adults which affects 2-4% of the world population. Keratinocytes are the key structural cells in epidermis which hyper-proliferate and undergo aberrant differentiation in psoriasis. LÄS MER

  5. 4. Impact of Mycobacterium tuberculosis and HIV-1 on innate immune mechanisms

    Författare :Jolanta Mazurek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human immunodeficiency virus type 1 (HIV-1), a causative agent of acquired immunodeficiency syndrome (AIDS), and Mycobacterium tuberculosis (Mtb), a causative agent of tuberculosis (TB), are among the leading causes of death from infectious disease worldwide. Interplay between HIV-1 and Mtb leads to the detrimental dysregulation of immune system mechanisms, which provides the conditions facilitating progression of the disease in co-infected individuals. LÄS MER

  7. 5. Nucleic Acids as Drug Targets - Influence of Platinum Complexes on Duplex Stability and Binding Kinetics

    Författare :Christopher Polonyi; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Anticancer drugs; platinum complexes; cisplatin; oxaliplatin; nucleic acid; RNA; DNA; duplex melting; thermodynamic stability; kinetics; non-coding RNA; miRNA; siRNA; wobble base pair; loop; BRCA1; mimic; luciferase assay;

    Sammanfattning : Gaining a detailed understanding of how human cells are affected by metal-based drugs is crucial, since these drugs have shown great potential in cancer treatment. Cisplatin is used to treat many different types of cancer, e.g. testicular, ovarian, melanoma, bladder, non-small cell lung cancer, small cell lung cancer, myelomas and lymphomas. LÄS MER