Sökning: "metabolome"

Visar resultat 11 - 15 av 48 avhandlingar innehållade ordet metabolome.

  1. 11. Systems Biology of Yeast Lipid Metabolism

    Författare :Pramote Chumnanpuen; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Transcriptome; Integrated analysis; Lipidome.; Inositol-choline; Opi1; Yeast lipid metabolism; high throughput techniques; Ino4; TORC1; Snf1; Ino2;

    Sammanfattning : Lipid metabolism plays an important role in the development of many different life-style related diseases, such as type 2 diabetes and atherosclerosis, and understanding the molecular mechanisms behind regulation of lipid biosynthesis and degradation may lead to development of new therapies. In this project we undertook a global study of lipid metabolism in the eukaryotic model organism Saccharomyces cerevisiae. LÄS MER

  3. 12. Metab-Immune analysis of the non-obese diabetic mouse

    Författare :Viqar Banday; Kristina Lejon; Åsa Andersson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NOD mouse; Type 1 diabetes; B cells; glutamic acid; metabolomics; immunologi; Immunology;

    Sammanfattning : Type 1A diabetes mellitus or T1D is a chronic disease characterized by T cell mediated destruction of the insulin producing β cells in the islets of Langerhans. The classical symptoms include high glucose levels in urine and blood, polyuria, and polydipsia. LÄS MER

  4. 13. Omics Techniques Applied to Diabetes Research - Focus on HSL-Null Mice and Clonal β-Cells

    Författare :Celine Fernandez; Molekylär endokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolomics; transcriptomics; treadmill; liver; HSL; cholesterol; proteomics;

    Sammanfattning : Diabetes mellitus is a disease characterized by increased blood glucose levels. For overt type 2 diabetes to develop, both insulin action and insulin secretion must be perturbed. LÄS MER

  5. 14. Image-based multi-omics data integration : Exploring whole-body PET/MRI, -omics data and body composition

    Författare :Robin Visvanathar; Håkan Ahlström; Joel Kullberg; Jan Eriksson; Katrine Riklund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Body composition; Imiomics; genomics; metabolomics; MRI; PET; insulin sensitivity; T2D;

    Sammanfattning : Advanced body composition analysis with whole-body imaging could uncover novel associations between regional tissue composition and metabolic disease. Imiomics is an automated image analysis framework that enables large-scale integration of magnetic resonance imaging (MRI) data and orthogonal technologies such as metabolomics and genomics for the detailed study of body composition. LÄS MER

  7. 15. Development of Protocols for Metabolomics in Biomedical Research using Chemometrics

    Författare :Anders Danielsson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; gas chromatography; design of experiments; Metabolomics; chemometrics; diabetes; metabolism; multivariate analysis;

    Sammanfattning : Metabolomics is a rapidly growing research field. It aims for quantification of all the metabolites in a biological sample such as plasma, saliva, cerebrospinal fluid or cells. LÄS MER