Sökning: "high throughput techniques"

Visar resultat 1 - 5 av 175 avhandlingar innehållade orden high throughput techniques.

  1. 1. Improved Techniques for High-Throughput Molecular Diagnostics

    Detta är en avhandling från Stockholm : Kemi

    Författare :Mario Curcio; [2002]
    Nyckelord :DNA; Molecular Diagnostics;

    Sammanfattning : The amount of information derived from sequencing the humangenome is leading to an exponential increase in the rate atwhich genes and genetic disorders are mapped and characterized.As a consequence, the demand for genetic testing is alsodramatically increasing. LÄS MER

  2. 2. Extreme Value Analysis of Huge Datasets: Tail Estimation Methods in High-Throughput Screening and Bioinformatics

    Detta är en avhandling från Göteborg : University of Gothenburg

    Författare :Dmitrii Zholud; Göteborgs universitet.; Gothenburg University.; [2011]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Extreme Value Statistics; High-Throughput Screening; HTS; Bioinformatics; analysis of huge datasets; quality control; correction of theoretical p-values; comparison of pre-processing methods; SmartTail; estimation of False Discovery Rates; test power; distribution tail; high level excursions; quantile estimation; multiple testing; Student t−test; Welch statistic; small sample sizes; F−test; Wiener process; Gaussian random walk; Shepp statistic; limit theorems; exotic options.; estimation of False Discovery Rates; distribution tail; F−test; high level excursions; multiple testing; High-Throughput Screening; small sample sizes; HTS; quality control; limit theorems; quantile estimation; comparison of pre-processing methods; SmartTail; Shepp statistic; Gaussian random walk; correction of theoretical p-values; Bioinformatics; Wiener process; test power; analysis of huge datasets; Student t−test; Welch statistic; exotic options.;

    Sammanfattning : This thesis presents results in Extreme Value Theory with applications to High-Throughput Screening and Bioinformatics. The methods described here, however, are applicable to statistical analysis of huge datasets in general. The main results are covered in four papers. LÄS MER

  3. 3. Droplet microfluidics for high throughput biological analysis

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Håkan Jönsson; Helene Andersson-Svahn; Andrew Griffiths; [2011]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Microfluidics; Droplet microfluidics; High throughput biology; Single cell analysis; Hydrodynamic separation; Enzyme amplification; Fluorescence polarization; Microfabrication; TECHNOLOGY Bioengineering; TEKNIKVETENSKAP Bioteknik; SRA - Molekylär biovetenskap; SRA - Molecular Bioscience;

    Sammanfattning : Many areas of biological research increasingly perform large-scale analyses.  In genomics the entire gene repertoire of an organism is analyzed.  Proteomics attempts to understand the function and expression patterns of all proteins in a cell or organism. LÄS MER

  4. 4. Miniaturized Techniques for Protein Analysis

    Detta är en avhandling från Stockholm : Kemi

    Författare :Johan Sjödahl; [2004]
    Nyckelord :Proteins; peptides; proteases; Antarctic krill; Euphausia superba; capillary electrophoresis; fluorosurfactants; mass spectrometry; nanoelectrospray; ESI; MALDI; chip; high-throughput; reproducibility; sensitivity; mass accuracy;

    Sammanfattning : Proteins are a highly diversified group of molecules, andfor their study, advanced analytical tools are required. Inparticular, a need for high-throughput techniques has emergedin order to enable the characterization of large sets ofproteins. LÄS MER

  5. 5. Towards High-Throughput Phenotypic and Systemic Profiling of in vitro Growing Cell Populations using Label-Free Microscopy and Spectroscopy Applications in Cancer Pharmacology

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Obaid Aftab; Mats Gustafsson; Neil Carragher; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; label free vesicle detector; high-throughput; phase contrast microscopy; Library of Pharmacologically Active Compounds; High Content Screening; fluorometric microculture cytotoxicity assay; nuclear magnetic resonance; mass spectrometry;

    Sammanfattning : Modern techniques like automated microscopy and spectroscopy now make it possible to study quantitatively, across multiple phenotypic and molecular parameters, how cell populations are affected by different treatments and/or environmental disturbances. As the technology development at the instrument level often is ahead of the data analytical tools and the scientific questions, there is a large and growing need for computational algorithms enabling desired data analysis. LÄS MER