Sökning: "lung volume"

Visar resultat 11 - 15 av 158 avhandlingar innehållade orden lung volume.

  1. 11. Cross-modal Imaging in Lung Research: From µCT dosimetry to synchrotron phase contrast microtomography biomechanical insights in preclinical lung injury models

    Författare :Richard Deyhle Jr; Malmö Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thermoluminescent Dosimetry; Optically stimulated luminescence OSL ; Computed tomography CT ; 4DCT; Phantoms; Imaging; X-rays; pre-clinical models; Pre-clinical; dosimetry: physical basis; biomedical strain; lung injury; mechanical ventilation; inflammation; lung function; synchrotron; histology; acute respiratory distress syndrome ARDS ; Ventilator Inudced Lung Injury VILI ; Histology; Forced Oscillation Technique FOT ; Divergence Theorem; Registration techniques;

    Sammanfattning : Lung diseases continue to present a large burden to public health, especially in industrialized countries. For abetter understanding of the underlying patho-mechanisms in lung related diseases as well as for testing theefficacy of novel therapies, preclinical studies in animal models are indispensable. LÄS MER

  3. 12. Monitoring alveolar recruitment in the critically ill - Patient studies using electric impedance tomography and volume-dependent compliance

    Författare :Karin Lowhagen; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALI; ARDS; compliance; end-expiratory lung volume; EELV; EIT; electric impedance tomography; lung recruitment; morbid obesity; PEEP; recruitment manoeuvre; regional ventilation; volume-dependent compliance;

    Sammanfattning : Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with a high mortality rate and poor long term outcome in terms of quality of life, for those who survive. Similarly, patients with morbid obesity are at risk for respiratory complications when subjected to anaesthesia and surgery. LÄS MER

  4. 13. Transpulmonary pressure during mechanical ventilation

    Författare :Christina Grivans; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mechanical ventilation; Acute lung injury; Acute respiratory distress syndrome; Lung volume measurements; Electric Impedance diagnostic use; Lung elastance; Transpulmonary pressure; Esophageal pressure;

    Sammanfattning : Background: Mechanical ventilation can aggravate lung injury by repetitive opening and closing of lung units, overdistention and undue pressure on pulmonary structures. Guidelines exist for lung protective ventilation, but individualized ventilator settings, based on partitioning of respiratory mechanics in pulmonary and chest wall complex components, would be beneficial. LÄS MER

  5. 14. Ventilation distribution in the lung periphery measured by inert gas washout : influence of increased gravity, anti-G suit pressure, body posture, and breathing pattern

    Författare :Mikael Grönkvist; Göran Hedenstierna; Linköpings universitet; []
    Nyckelord :acceleration; anti-G suit; body posture; cdi; dcdi; human centrifuge; He; hypergravuty; lung; multiple-breath washout; single-breath washout; SF 6; standing; supune; trapped gas; ventilation distribution; MEDICINE; MEDICIN;

    Sammanfattning : The lung is highly sensitive to forces of gravity and acceleration, and to surrounding pressures. This thesis aimed to assess the effects on ventilation distribution in peripheral lung units when changing the direction or magnitude of the gravitational vector and when compressing the lower body half with an anti-G suit (AGS). LÄS MER

  7. 15. The Immune Response to One-Lung Ventilation : Clinical and Experimental Studies

    Författare :Thomas Schilling; Göran Hedenstierna; Hans Hedenström; Thomas Hachenberg; Sven-Erik Ricksten; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; One-lung ventilation; open thoracic surgery; ventilation-induced lung injury; alveolar immune response; bronchoalveolar lavage; propofol; desflurane; cytokines; animal model; mRNA; RT-PCR; Medical laboratory science; Medicinsk laboratorievetenskap; anestesiologi; Anaesthesiology;

    Sammanfattning : One-lung ventilation (OLV) as an established procedure during thoracic surgery may be injurious in terms of increased mechanical stress characterised by alveolar cell stretch and overdistension, increased cyclic tidal recruitment of alveolar units, compression of alveolar vessels and increased pulmonary vascular resistance. This may result in ventilation-induced lung injury with pro-inflammatory cytokine production, leukocyte recruitment and neutrophil-dependent tissue destruction. LÄS MER