Sökning: "infectivity"

Visar resultat 1 - 5 av 72 avhandlingar innehållade ordet infectivity.

  1. 1. Novel inhibitors of Chlamydia trachomatis virulence

    Författare :Carlos Nunez-Otero; Åsa Gylfe; Sven Bergström; Fredrik Almqvist; Jörgen Johansson; Patrik Bavoil; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chlamydia trachomatis; 2-pyridone; small molecules; KSK213; Structure-Activity Relationships SAR ; antibiotic resistance; target identification; transcription; RNA; progeny; infectivity;

    Sammanfattning : Chlamydia trachomatis is an obligate intracellular bacterium that infects over 100 million people globally every year. Chlamydia infections can be persistent, cause infertility and blindness, adding an economical burden in the healthcare systems. LÄS MER

  3. 2. Physics of Viral Infectivity: Energetics of Genome Ejection

    Författare :Meerim Jeembaeva; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; microfluidics.; differential scanning calorimetry; capsid; Key words: phage; osmotic suppression; DNA ejection; isothermal titration calorimetry; enthalpy;

    Sammanfattning : All viruses that infect bacteria, plant, or animal cells involve a genome (RNA or DNA) that is encapsidated by a rigid protein shell. After delivery of the viral genome into the host cell, new capsid proteins, which are encoded by viral DNA or RNA, are expressed and self-assembled into new viral capsids. LÄS MER

  4. 3. Factors Influencing Evolution to Antimalarial Drug Resistance in Plasmodium falciparum in Sudan and The Gambia

    Författare :Amany Kheir; Göte Swedberg; Susanne Kerje; Hamza Babiker; Staffan Svärd; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cross-mating; fitness; microsatellite haplotypes; mosquito infectivity; Infectious diseases; Infektionssjukdomar; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Drug resistance is a major obstacle to management and control of malaria and currently progressing at a rapid rate across Africa. This thesis has examined factors influencing evolution of resistant P. falciparum at two sites in Africa, including parasite migration, cross mating and fitness cost of resistance. LÄS MER

  5. 4. Altering HIV-1 envelope glycoprotein maturation and its effects on viral infectivity

    Författare :Alenka Jejcic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1;

    Sammanfattning : HIV-1 is dependent on its envelope glycoprotein (Env) to initiate infection. Env binds to cellular receptors and mediate the following fusion of the viral envelope with the cell plasma membrane. LÄS MER

  7. 5. Effect of the tri-peptide glycyl-prolyl-glycine amide on HIV-1 replication

    Författare :Jin Su; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; antiretrovirals; peptides; tri-peptides; GPG-NH2; capsid formation; p24 dimerization; coneshaped core; GPG motif; V3 loop; infectivity;

    Sammanfattning : The human immunodeficiency virus type 1 (HIV-1) is the etiological agent responsible for AIDS worldwide. The aim of this thesis was to evaluate the anti-HIV-1 activity of short peptides and to investigate their mode of inhibition. LÄS MER