Sökning: "GPG-NH2"

Hittade 3 avhandlingar innehållade ordet GPG-NH2.

  1. 1. Short modified peptides and their metabolites inhibit HIV replication

    Författare :Elin Andersson; Göteborgs universitet; []
    Nyckelord :HIV-1; AIDS; GPG-NH2; G-NH2; antiretroviral drugs; Dipeptidyl peptidase IV; CD26; prodrug;

    Sammanfattning : Several drugs inhibiting the replication of HIV-1, the causative agent of AIDS, are available today. However, HIV-1 treatment is hampered by side effects, poor adherence and development of resistance. LÄS MER

  3. 2. Effect of the tri-peptide glycyl-prolyl-glycine amide on HIV-1 replication

    Författare :Jin Su; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; antiretrovirals; peptides; tri-peptides; GPG-NH2; capsid formation; p24 dimerization; coneshaped core; GPG motif; V3 loop; infectivity;

    Sammanfattning : The human immunodeficiency virus type 1 (HIV-1) is the etiological agent responsible for AIDS worldwide. The aim of this thesis was to evaluate the anti-HIV-1 activity of short peptides and to investigate their mode of inhibition. LÄS MER

  4. 3. Altering HIV-1 envelope glycoprotein maturation and its effects on viral infectivity

    Författare :Alenka Jejcic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1;

    Sammanfattning : HIV-1 is dependent on its envelope glycoprotein (Env) to initiate infection. Env binds to cellular receptors and mediate the following fusion of the viral envelope with the cell plasma membrane. LÄS MER