Sökning: "V3 loop"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden V3 loop.

  1. 1. HIV-1 envelope protein gp120. Glycovirology of the V3 loop

    Författare :Britt Losman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AIDS; HIV-1; Carbohydrates; V3-region; V1-region; Coreceptors;

    Sammanfattning : The human immunodeficiency virus type 1 (HIV-1) infection usually is lethal as a consequence of the acquired immunodeficiency syndrome (AIDS). HIV-1 is an enveloped virus and the trimeric envelope glycoprotein complex, gp120/gp41, is responsible for binding of the virus both to the primary cellular receptor CD4 and the coreceptors, CXCR4 and CCR5. LÄS MER

  3. 2. Biological correlates of HIV-1 heterosexual transmission

    Författare :José Ramón Fiore; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1 sexual transmission HIV-1 biological phenotypelneutralizing antibodies V3 loop antibodies infectiousness disease progression drug resistance;

    Sammanfattning : HIV-1 infection is a sexually transmitted disease but HIV transmission efficiency by sexual contacts appears to be highly variable; this is probably due to the influence that several behavioural, clinical and biological factors exert on the transmission event. Here we focused on possible biological correlates of HIV sexual transmission, with emphasis on the host antibody response towards HIV and the virus biological characteristics. LÄS MER

  4. 3. Effect of the tri-peptide glycyl-prolyl-glycine amide on HIV-1 replication

    Författare :Jin Su; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; antiretrovirals; peptides; tri-peptides; GPG-NH2; capsid formation; p24 dimerization; coneshaped core; GPG motif; V3 loop; infectivity;

    Sammanfattning : The human immunodeficiency virus type 1 (HIV-1) is the etiological agent responsible for AIDS worldwide. The aim of this thesis was to evaluate the anti-HIV-1 activity of short peptides and to investigate their mode of inhibition. LÄS MER

  5. 4. HIV-1 variability in relation to host defence mechanisms and disease outcome

    Författare :Marianne Jansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; peptides; seroreactivity; genetic variability; pediatric; disease outcome; biological phenotypes; B-chemokines; coreceptors; V3; V2.;

    Sammanfattning : Genetic variability is a major characteristic of HIV-1. Virus variants evolve rapidly, not only globally, but also within single individuals as a result of an error-prone reverse transcriptase, a rapid virus population turnover and selective pressure from the host. LÄS MER

  7. 5. Studies on HIV-2 antibody mediated neutralisation, coreceptor usage and in vivo tropism

    Författare :Andreas Mörner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-2; neutralising antibodies; V3; combinatorial library; phage display; Fab fragment; coreceptor; CCR5; CXCR4; HIV encephalitis; macrophages microglia;

    Sammanfattning : Human immunodeficiency virus type 2 (HIV-2) is the second virus that causes AIDS in humans. It has a genetic identity with HIV-1 of 40-60% and similar genetic organisation and biological properties, but the two viruses are distinguished certain features. LÄS MER