Sökning: "in-vivo"

Visar resultat 11 - 15 av 3545 avhandlingar innehållade ordet in-vivo.

1. 11. Motion and Emotion : Functional In Vivo Analyses of the Mouse Basal Ganglia

   Författare :Emma Arvidsson; Åsa Wallén-Mackenzie; Cecilia Flores; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopamine; Basal Ganglia; Reward System; In Vivo Chronoamperometry; Optogenetics; Deep Brain Stimulation; Parkinson’s Disease; Addiction; Glutamate; Vesicular Glutamate Transporter; VGLUT2; Sex; Age; Subthalamic Nucleus; Striatum; Nucleus Accumbens; Ventral Tegmental Area;

   Sammanfattning : A major challenge in the field of neuroscience is to link behavior with specific neuronal circuitries and cellular events. One way of facing this challenge is to identify unique cellular markers and thus have the ability to, through various mouse genetics tools, mimic, manipulate and control various aspects of neuronal activity to decipher their correlation to behavior. LÄS MER

3. 12. Regulation of Ovarian Aromatase: Studies by Aromatase Assays in vitro and in vivo

   Författare :Dmitrijus Kirilovas; Mats Brännström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; aromatase; human; granulosa cells; 11C-vorozole; active site; allosteric configuration; in vitro; in vivo; PET; androgens; rat; estrous cycle.; Obstetrik och kvinnosjukdomar; Obstetrics and women s diseases; Obstetrik och kvinnosjukdomar; Obstetrics and Gynaecology; obstetrik och gynekologi;

   Sammanfattning : An in vitro method was developed for measuring aromatase, based on binding of competitive aromatase inhibitor [11C]vorozole to the active site of the enzyme. [11C]Vorozole displayed high, specific binding in vitro to human placenta and human granulosa cells (GC), both fresh and frozen/thawed cells, provided correct procedures were used. LÄS MER

4. 13. Mechanisms of Osseointegration: Experimental Studies on Early Cellular and Molecular Events in vivo

   Författare :Omar Omar; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osseointegration; titanium; bone; gene expression; bone-implant interface; qPCR; inflammation; cytokine; chemotaxis; chemokine; integrin; bone formation; remodeling; in vivo; rat; immunohistochemistry; ultrastructure; biomechanical torque test;

   Sammanfattning : The early cellular and molecular activities determining the early tissue response and bone formation at bone/implant interface are not fully understood. The general aim of the current thesis was to develop a model for studying the early molecular and cellular activities in different bone types, and in response to different implant surface properties. LÄS MER

5. 14. Mechanical Properties of Arteries : An In Vivo Parameter Identification Method

   Författare :Jan-Lucas Gade; Jonas Stålhand; Carl-Johan Thore; Stéphane Avril; Linköpings universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

   Sammanfattning : In this dissertation, a method is proposed that identifies the mechanical properties of arteries in vivo. The mechanical properties of an artery are linked to the development of cardiovascular diseases. LÄS MER

7. 15. Up-regulation of dopamine D₂ receptors : in vitro and in vivo studies

   Författare :Maria Wanderoy; Eliassitet Eriksson; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; neurokemi och neurotoxikologi; Neurochemistry and Neurotoxicology;

   Sammanfattning : In the central nervous system (CNS) dopaminergic and dopaminoceptive neurons have the ability to respond to variations in dopamine levels by for example adjusting their dopamine receptor levels. One of the most well known phenomena in this respect is that long-term blockade of D2 receptors with antipsychotic drugs leads to an increase in striatal D2 receptor density of experimental animals as well as of schizophrenic patients as measured in both post-mortem studies and in vivo positron emission tomography studies of brain. LÄS MER