Sökning: "in silico prediction"

Visar resultat 16 - 20 av 27 avhandlingar innehållade orden in silico prediction.

  1. 16. Preclinical investigation of novel therapies against neuroblastoma

    Författare :Karin Hansson; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Neuroblastoma; Translational research; Preclinical drug evaluation;

    Sammanfattning : Neuroblastoma is a childhood tumor of the sympathetic nervous system and the most common tumor form diagnosed in infants. Patients with aggressive tumors are treated intensely with multi-modal therapy including chemotherapy, surgery, radiotherapy and immunotherapy. LÄS MER

  3. 17. Behind the scenes of thyroid tumors : underlying genetic mechanisms

    Författare :Jia Jing Lee; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Familial medullary thyroid cancer; follicular thyroid cancer; anaplastic thyroid cancer; CCND1; UBCH10; p16; RASSF1A; BRAF; array-CGH; tumor progression; global methylation; LINE-1; LUMA;

    Sammanfattning : Thyroid cancer is the most frequently observed malignancy involving endocrine tissues. This group of diseases is also the major cause of death related to neoplasia of the endocrine system. Tumors in the thyroid gland are common in the general population and the majority represents benign follicular adenoma (FTA). LÄS MER

  4. 18. Computational and experimental approaches to regulatory genetic variation

    Författare :Malin Andersen; Jacob Odeberg; John Peden; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Molecular biology; Genetics; single nucleotide polymprhism SNP ; regulatory SNP; transcription factor binding site; phylogenetic footprinting; allelic imbalance; EMSA; CD36; cardiovascular disease.; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik;

    Sammanfattning : Genetic variation is a strong risk factor for many human diseases, including diabetes, cancer, cardiovascular disease, depression, autoimmunity and asthma. Most of the disease genes identified so far alter the amino acid sequences of encoded proteins. LÄS MER

  5. 19. The labyrinth of protein classification: a pipeline forselection and classification of biological data

    Författare :Benedetta Pelosi; Neus Visa; Antonio Barragan; Stefan Jansson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; pipeline; filtering; machine learning; deep learning; computational biology; bioinformatics; mitochondrial metabolism; carotenoid biosynthesis; orthologs; protein analyses; statistics; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics; statistik; Statistics;

    Sammanfattning : Recent progress in fundamental biological sciences and medicine has considerably increased the quantity ofdata that can be studied and processed. The main limitation now is not retrieving data, but rather extractinguseful biological insights from the large datasets accumulated. LÄS MER

  7. 20. MHC class I - Peptide binding and complex stability

    Författare :Elna Follin; Antigen presentation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The major histocompatibility class I (MHC-I) genes are highly polymorphic and the proteins that they encode play a crucial role in both the innate and the adaptive immune response. A MHC-I molecule consists of three parts, one polymorphic heavy chain, one invariant light chain, β2-microglobulin and a peptide of usually between 8-11 amino acids in length. LÄS MER