Sökning: "orthologs"
Visar resultat 1 - 5 av 43 avhandlingar innehållade ordet orthologs.
1. The labyrinth of protein classification: a pipeline forselection and classification of biological data
Sammanfattning : Recent progress in fundamental biological sciences and medicine has considerably increased the quantity ofdata that can be studied and processed. The main limitation now is not retrieving data, but rather extractinguseful biological insights from the large datasets accumulated. LÄS MER
2. Functional Inference from Orthology and Domain Architecture
Sammanfattning : Proteins are the basic building blocks of all living organisms. They play a central role in determining the structure of living beings and are required for essential chemical reactions. One of the main challenges in bioinformatics is to characterize the function of all proteins. LÄS MER
3. Deciphering molecular mechanisms in the evolution of new functions
Sammanfattning : The evolution of new genes and functions is considered to be a major contributor to biological diversity in organisms. Through de novo origination, “duplication and divergence”, and horizontal gene transfer, organisms can acquire new genetic material that can evolve to perform novel functions. LÄS MER
4. Analyses of protein evolution, function, and architecture
Sammanfattning : Proteins can evolve over time in many different ways. An ancestral protein sequence inherited in different species will gradually undergo changes in primary sequence and sometimes in domain architecture. Some of these changes will affect its function, and evolutionary analyses can be used to predict function shift. LÄS MER
5. Big data networks and orthology analysis
Sammanfattning : Understanding biological systems in complex organisms is important in life science in order to comprehend the interplay of genes, proteins, and compounds causing complex diseases. As biological systems are intricate, bioinformatics tools, models, and algorithms are of the utmost importance to understand the bigger picture and decipher biological meaning from the vast amounts of information available from biological experiments and predictions. LÄS MER