Sökning: "global methylation"
Visar resultat 1 - 5 av 57 avhandlingar innehållade orden global methylation.
1. Placental molecular mechanisms as pathways linking prenatal exposure to ambient air pollution to preeclampsia and fetal growth
Sammanfattning : Background: Preeclampsia (PE) is a “multifactorial syndrome” in which ambient air pollution may contribute to the etiology of PE. However, the underlying mechanism of this association is not clearly elucidated. LÄS MER
2. Molecular Genetic and DNA Methylation Profiling of Chronic Lymphocytic Leukaemia : A Focus on Divergent Prognostic Subgroups and Subsets
Sammanfattning : Advancements in prognostication have improved the subdivision of chronic lymphocytic leukaemia (CLL) into diverse prognostic subgroups. In CLL, IGHV unmutated and IGHV3-21 genes are associated with a poor-prognosis, conversely, IGHV mutated genes with a favourable outcome. LÄS MER
3. Genetics, epigenetics and functional mechanisms in inherited corneal and retinal dystrophies
Sammanfattning : Inherited eye disorders (IED) are groups of genetically and clinically heterogenous conditions affecting different tissues in the eye. IED are most often progressive with reduced vision or legal blindness as outcome. LÄS MER
4. Genomic characterization of non-small cell lung cancer - clinical and molecular implications
Sammanfattning : Lung cancer accounts for 1.6 million cancers annually and 1.3 million deaths per year make the disease the deadliest type of cancer. Smoking is the most prominent cause. LÄS MER
5. Exploring vitamin D and steroid hormone receptors – from healthy elderly to prostate cancer cells
Sammanfattning : The genetic background together with environmental factors and lifestyle are key contributors to the health of an individual. Genetic background is inherited and irreversible unless mutations occur. However, lifestyle habits (i.e. LÄS MER