Sökning: "AGRP"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet AGRP.

  1. 1. Hypothalamic neuronal circuits involved in the regulation of food intake and body weight : histochemical studies in lean rats and obese mutant mice

    Författare :Matilda Bäckberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :AGRP; arcuate nucleus; BBB; CART; GABA; GABA receptors; immunohistochemistry; in situ hybridization; hypothalamus; LHA; leptin; MCH; NPY; orexin; POMC; tubby;

    Sammanfattning : Obesity is a major health problem because of its dramatic increase in prevalence and its association with type 2 diabetes, coronary heart diseases, hypertension and stroke. It is well known that signals generated in response to feeding behavior are integrated in the brain. LÄS MER

  3. 2. Brain control of energy balance : localization and regulation of proteins involved in the central control of food intake and body weight

    Författare :Maria Collin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :AGRP; arcuate nucleus; brainstem; CART; GABA; Glutamate; GPCR; habenular complex; immunohistochemistry; in situ hybridization; hypothalamus; leptin; leptin receptor; LHA; MCH; NPY; Ob-Rb; POMC; serotonin; STAT3; transporter; ventromedial hypothalamic nucleus; VGLUT1-3.;

    Sammanfattning : Obesity has become a worldwide threat to human well-being and is now so common that it is beginning to replace undernutrition and infectious disease as the most significant contributor to ill health. Obesity increases the risk for aquiring serious diseases such as diabetes type 2, hypertension, coronary heart disease and certain forms of cancer. LÄS MER

  4. 3. Leptin targets in the brain regulating body weight : receptors and down-stream mediators of leptin in neurons of the hypothalamus and brainstem

    Författare :Marie-Louise Håkansson Ovesjö; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :AGRP; antibody; arcuate nucleus; blood-brain-barrier; body weight; brainstem; CART; CRH; DMX; food intake; GABA; GAD; galanin; hypothalamus; immunohistochemistry; in situ hybridization; lateral hypothalamic area; leptin; leptin receptor; MCH; NPY; obesity; Ob-R; Ob-Rb; oxytocin; paraventricular nucleus; POMC; somatostatin; serotonin; STAT3; supraoptic nucleus; transcription factor; vasopressin; VGAT;

    Sammanfattning : Obesity is a disease which has become a global epidemic that is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health in the world. In particular, obesity is associated with diabetes mellitus, hypertension and coronary heart disease. LÄS MER

  5. 4. Appetite control : genetic, immunological and neurobiological aspects

    Författare :Charlotte Lindfors; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The overall goal of this thesis is to develop a better understanding of the brain’s regulation of appetite, i.e. the hypothalamic regulation of hunger and satiety signals. LÄS MER

  7. 5. Hypothalamic regulation of food intake : focus on the anx/anx mouse

    Författare :Ida Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main goal of this thesis is to increase the knowledge about one of the most important tasks of the brain, the hypothalamic regulation of food intake. The hypothalamus is considered to be the brain s main center for regulation of food intake and it is integrating signals regaring energy status, from the body, to initiate a proper behavioral response. LÄS MER