Sökning: "heterocyclic aromatic amine"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden heterocyclic aromatic amine.

  1. 1. New methods for the synthesis of N-heteroaromatics and imines

    Författare :Kenji Kopf; Belén Martín Matute; Joseph P. A. Harrity; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; heterocyclic; heteroaromatic; atropisomer; pyridine; pyrimidine; MOF; amine coupling; catalysis; benzannulation; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis is divided in four chapters, containing the work realised in two universities and has as the aim the synthesis of nitrogen-containing compounds. The first chapter describes the project realised at The University of Sheffield. LÄS MER

  3. 2. Regulation of dioxin receptor function by procarcinogenic food-derived heterocyclic amines and indolocarbazoles

    Författare :Marika I Kleman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :heterocyclic aromatic amine; indolocarbazole; dioxin receptor; CYPlA;

    Sammanfattning : Cooking of protein-rich food generates procarcinogenic heterocyclic aromatic amines(HCA) in amounts that range in the part per billion levels. The capacity of the two most prevalent HCA, PhIP and MelQx, to induce genetic alterations in vivo was determined using a short-term liver carcinogenesis model (RH-model) in rat. LÄS MER

  4. 3. Bioactivation and binding of polycyclic aromatic hydrocarbons in blood vessel endothelia

    Författare :Lizette Granberg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Polycyclic aromatic hydrocarbon; PAH; endothelial cells; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; Ecotoxicology; ekotoxikologi;

    Sammanfattning : Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants formed by incomplete combustion of organic materials such as fossil fuels and wood. Experimental and epidemiological studies indicate that PAHs may be involved in the development of cardiovascular disease. LÄS MER

  5. 4. Capillary electroseparations with mass spectrometric detection Nanoparticle-based continuous full filling and applications for complex sample matrices

    Författare :Peter Viberg; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytisk kemi; Analytical chemistry; phthalates; continuous full filling; heterocyclic aromatic amines; pseudostationary phase; capillary electrophoresis; electrokinetic chromatography; capillary electrochromatography; nanoelectrospray; mass spectrometry;

    Sammanfattning : One of the major challenges in analytical chemistry is to find techniques and methods for determinations of low abundance compounds in complex sample matrices. This thesis describes the development of new miniaturised analytical techniques comprising capillary electroseparation combined with mass spectrometric detection. LÄS MER

  7. 5. Design, Synthesis, Mechanistic Rationalization and Application of Asymmetric Transition-Metal Catalysts

    Författare :Christian Hedberg; Pher G. Andersson; Hans-Ulrich Blaser; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; asymmetric catalysis; homogeneous hydrogenation; iridium; ruthenium; ligand design; mechanistic studies; kinetics; tolterodine; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis describes mechanistic studies, rational ligand design, and synthesis of asymmetric transition metal catalysts. The topics addressed concerned [Papers I-VII]:[I] The asymmetric addition of diethyl zinc to N-(diphenylphosphinoyl)benzalimine catalyzed by bicyclic 2-azanorbornyl-3-methanols was studied. LÄS MER