Sökning: "growth inhibition"

Visar resultat 31 - 35 av 646 avhandlingar innehållade orden growth inhibition.

1. 31. Growth factor pathways in human cancer : functional and therapeutic implications

   Författare :Leonard Girnita; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :IGF-1R; growth factors; p53; fusion protein; tyrosine kinase inhibitors; ubiquitin;

   Sammanfattning : The multi-step development of tumors involves numerous changes at genomic level such as oncogene activation, loss of function of tumor suppressor genes and translocations resulting in fusion genes that encodes for chimeric proteins with tumorigenic functions etc. However, in the selection leading to cancer in somatic tissues it is likely that the cancer cells make use of the normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. LÄS MER

3. 32. Mechanisms of Regulation of the Cell Cycle Inhibitor p21Waf1/Cip1 in TGF-β-Mediated Cell Growth Inhibition

   Författare :Katerina Pardali; Aristidis Moustakas; Carl-Hernrik Heldin; Marikki Laiho; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; TGF-β; cell cycle; p21; Smad; signal transduction; transcription; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : TGF-β is the founding member of a multifunctional family of cytokines that regulate many aspects of cell physiology, including cell growth, differentiation, motility and death and play important roles in many developmental and pathological processes. TGF-β signals by binding to a heterotetrameric complex of type I and type II serine/threonine kinase receptors. LÄS MER

4. 33. IGF-1R inhibition : a tool for functional studies of insulin-like growth factor family in malignant cells

   Författare :Daiana Vasilcanu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :IGF-1R; chemoresistance; IR; glucose uptake; tyrosine kinase inhibitors;

   Sammanfattning : Cancer cells generally posses the capability of overusing normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. Major players in extracellular signaling are the growth factor receptors. Among them, an activated IGF-1R is important for the establishment of a malignant cell phenotype. LÄS MER

5. 34. Influence of Lactic Acid Fermentation on Enteropathogenic Bacteria. Growth Inhibition in Cereal Gruels and in Human Intestine

   Författare :Rose Kingamkono; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; intestinal mucosal permeability; enteropathogenic bacteria; enterotoxins; lactic acid fermentation;

   Sammanfattning : Togwa, a lactic-fermented cereal gruel, is widely consumed in Tanzania as a soft drink or used as a complementary food for young children. Studies were conducted to evaluate the potential of togwa to inhibit growth of common enteropathogenic bacteria and heat-labile (LT) enterotoxin production. LÄS MER

7. 35. Targeting insulin-like growth factor-1 receptor in cancer

   Författare :Ada Girnita; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :IGF1; IGF-1R; MDM2; p53; PPP; Tamoxifen; tyrosine kinase inhibitors; ubiquitin;

   Sammanfattning : Cancer is a multi-step process where the accumulation of several genetic and epigenetic alterations drives the transformation of a normal cell to a malignant cell, skipping the normal control of defense, repair and apoptosis. During the selection process towards a malignant phenotype, the transforming cells make use of normal (physiological) extracellular signaling pathways to create growth advantage over normal cells. LÄS MER