Sökning: "chemoresistance"

Visar resultat 1 - 5 av 28 avhandlingar innehållade ordet chemoresistance.

  1. 1. Molecular signatures of progression and chemoresistance in epithelial ovarian carcinoma

    Författare :My Björklund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epithelial ovarian carcinoma (EOC) is a heterogeneous disease generally classified into five histopathological subtypes; low- and high-grade serous, endometrioid, clear cell and mucinous carcinomas. Although each subtype has distinct clinical and molecular characteristics, they are all treated with surgery and platinum/ taxane chemotherapy. LÄS MER

  3. 2. Apoptosis signaling in leukemia and lymphoma: understanding mechanisms of chemoresistance

    Författare :Astrid Ottosson Wadlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Apoptosis (programmed cell death) is a basic physiological process, essential in the balance between life and death of cells of normal tissues in the body. Apoptosis can be considered as cellular “suicide” initiated by the cell itself when infected by a virus or transformed into a cancer cell. LÄS MER

  4. 3. Circumventing drug resistance : Studies exploring the expediency of a total cell kill chemoresistance assay

    Författare :Bertil Jonsson; Uppsala universitet; []
    Nyckelord :Medical sciences; drug resistance; drug resistance assay; clinical correlations; cancer; human; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : Cellular resistance to anti-cancer drugs is considered to be the major cause of treatment failure in clinical practice. The present studies have therefore focused on ways to circumvent resistance as evaluated by an in vitro chemoresistance assay. LÄS MER

  5. 4. IGF-1R inhibition : a tool for functional studies of insulin-like growth factor family in malignant cells

    Författare :Daiana Vasilcanu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IGF-1R; chemoresistance; IR; glucose uptake; tyrosine kinase inhibitors;

    Sammanfattning : Cancer cells generally posses the capability of overusing normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. Major players in extracellular signaling are the growth factor receptors. Among them, an activated IGF-1R is important for the establishment of a malignant cell phenotype. LÄS MER

  7. 5. Receptor tyrosine kinase signaling and extracellular matrix cues in ovarian cancer metastasis and drug resistance

    Författare :Lidia Moyano Galceran; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Albeit many studies have contributed towards understanding the origin, development, treatment response and evolution of high-grade serous ovarian carcinoma (HGSC), the exact supporting mechanisms are still not fully understood, and the disease remains a clinical challenge with low 5-year survival and high recurrence rate. The purpose of this thesis was to study the dynamic communication between the cancer cells and the tumor microenvironment (TME) to understand how these influence and are affected by disease progression and chemotherapy in the context of HGSC. LÄS MER