Sökning: "gfap"

Visar resultat 11 - 15 av 100 avhandlingar innehållade ordet gfap.

1. 11. EMBRYONIC GLIA AND FOREBRAIN NEUROGENESIS; in vitro generation and differentiation of telencephalic neurons

   Författare :Charlotta Skogh; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; beta tubulin III; GFAP; RC2; Neurology; neuropsychology; neurofysiologi; DARPP-32; retinoic acid; serum; EGF; co-culture; cell culture; striatum; LGE; progenitor; precursor; radial glia; region specific; development; CNS; mouse; human; neurophysiology; Neurologi; neuropsykologi;

   Sammanfattning : The current thesis is aimed to increase our understanding of the generation and differentiation of telencephalic neurons, with emphasis on the role of glial cells in these processes. Using in vitro methods we have studied the role of glial cells in neurogenesis, inheritance of genetic regional specification, and influence on differentiation of neurons. LÄS MER

3. 12. Preclinical PET imaging and therapy of Alzheimer's disease

   Författare :Silvio R. Meier; Stina Syvänen; Dag Sehlin; Greta Hultqvist; Matthias Brendel; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta; positron emission tomography PET ; bispecific antibody; BACE-1; TREM2; GFAP; Molekylär medicin; Molecular Medicine; Neuroscience; Neurovetenskap;

   Sammanfattning : The main histopathological hallmarks of Alzheimer’s disease are extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles, containing tau protein. Because of misfolded and aggregated proteins, activated microglia and astroglia react with a neuroinflammatory response, which may contribute to disease progression and severity. LÄS MER

4. 13. Assessment of experimental neurotrauma

   Författare :Ying-Lai Huang; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Impulse noise; diffuse brain injury; focal brain injury; closed head injury; NSE; S-100; GFAP; apoptosis; astrocytosis; glutamate; c-JUN; rotational acceleration; CSF;

   Sammanfattning : Model systems of closed head injury are designed to replicate aspects of traumatic brain injury, ischemia and epilepsy in man. The aim of this thesis was to (1) develop sensitive systems enabling analyses of the biochemical reactions, as reflected by leakage of marker compounds to the cerebrospinal fluid (CSF); and (2) develop and assess a new model for closed head injury and associated dynamic changes in the brain cell. LÄS MER

5. 14. The importance of astroglial cells in ischemia, regeneration and angiogenesis

   Författare :Andrea Lundkvist; Göteborgs universitet; []
   Nyckelord :astrocytes; Müller cells; retina; intermediate filaments; GFAP; vimentin; angiogenesis; VEGF-A; guidance; matrix-metalloprotease;

   Sammanfattning : Astrocytes in the CNS communicate with both neurons and blood vessels. In many CNS pathologies, astrocytes respond by becoming reactive. Whether their performance at this stage is beneficial or detrimental for CNS function is unclear. LÄS MER

7. 15. Functional studies of the Quaking gene : Focus on astroglia and neurodevelopment

   Författare :Katarzyna Radomska; Elena Jazin; Pertti Panula; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; QKI; RNA-binding protein; astrocyte; interferon; GFAP; neurodevelopment; zebrafish; neural progenitor cell;

   Sammanfattning : The RNA-binding protein Quaking (QKI) plays a fundamental role in post-transcriptional gene regulation during mammalian nervous system development. QKI is well known for advancing oligodendroglia differentiation and myelination, however, its functions in astrocytes and embryonic central nervous system (CNS) development remain poorly understood. LÄS MER