Sökning: "genome integrity"

Visar resultat 11 - 15 av 60 avhandlingar innehållade orden genome integrity.

  1. 11. Investigating the molecular mechanism of photoprotection, qH, in Arabidopsis thaliana

    Författare :Pierrick Bru; Alizée Malnoë; Stefano Caffarri; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Photosynthesis; Photoprotection; non photochemical quenching; qH; genetic screen; genome editing; biology; biologi; Biochemistry; biokemi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Photoprotection mechanisms in plants play a crucial role in maintaining photosystem integrity and preventing photooxidative damage. In this study, we aimed to identify new molecular players involved in the qH process, a sustained photoprotective mechanism. LÄS MER

  3. 12. Structural maintenance of chromsomes : a complex tale of genomic integrity

    Författare :Hanna Betts Lindroos; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Genomic integrity is an absolute requirement for cell survival. Programmed events such as genome rearrangements and DNA replication can cause lesions in the DNA, as can exogenous agents such as radiation and chemicals. One of the most austere types of lesion is DNA double strand breaks (DBSs). LÄS MER

  4. 13. p53 guardian of the genome and target for improved treatment of leukemia

    Författare :Hareth Nahi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :p53; p14ARF; PRIMA; RITA; AML; CLL; HDM-2;

    Sammanfattning : P53 acts in several cellular processes as cell cycle checkpoints, DNA repair senescence and the surveillance of genomic integrity. Wt p53 inhibits cancer processes by causing cell cycle arrest and apoptosis. P53 is strongly regulated by the HDM-2 protein, which builds a complex with p53 leading to proteosomal degradation of p53. LÄS MER

  5. 14. Ribonucleotides in DNA - Application in genome-wide DNA polymerase tracking and physiological role in eukaryotes

    Författare :Katrin Kreisel; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ribonucleotides; DNA instability; DNA polymerase eta; nuclear DNA; mitochondrial DNA;

    Sammanfattning : The genetic code in the eukaryotic cell is stored in the form of DNA, which is more resistant to hydrolysis than RNA. Replication fidelity and DNA repair mechanisms are in place to ensure genomic integrity to preserve the information encoded. LÄS MER

  7. 15. The role of the cohesin loader in genome stability : a journey from yeast to human

    Författare :Fosco Giordano; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Structural Maintenance of Chromosome (SMC) complexes, as their name suggests, have a central role in maintaining the higher structure of genomes, from bacteria to human, and in doing so protecting their integrity. Cohesin, one of three SMC complexes, is required to hold sister chromatids together until anaphase, and for homologous recombination-based DNA repair. LÄS MER