Sökning: "genome integrity"

Visar resultat 21 - 25 av 60 avhandlingar innehållade orden genome integrity.

  1. 21. Allosteric Regulation and Radical Transfer in Ribonucleotide Reductase

    Författare :Karl-Magnus Larsson; Pär Nordlund; Derek Logan; Roger Kornberg; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allosteric regulation; substrate specificity; ribonucleotide reductase; radical; Biochemistry; Biokemi;

    Sammanfattning : The stability of biological life over time requires that the integrity of the genetic material of an organism, the genome, be maintained as it is passed on from one generation to the next. All known cellular life has DNA-based genomes, which are duplicated before each cell division in a process called replication. LÄS MER

  3. 22. Towards a cohesive understanding of the DNA damage response as a therapeutic target

    Författare :Martin Scherzer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : At the basis of the complexity that forms a human being is a highly regulated interplay of factors found at a molecular, cellular, and macroscopic level. Ever since we evolved to work this way, even the slightest dysregulation at the molecular level can cascade and manifest as a non-communicable disease which ultimately affects the whole organism. LÄS MER

  4. 23. DNA precursor asymmetries, Mismatch Repair and their effect on mutation specificity

    Författare :Robert Buckland; Andrei Chabes; Juan Méndez; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA Replication Fidelity; Mutations; dNTP pools; Mismatch Repair; Checkpoint; Ribonucleotide Reductase; Msh2; medicinsk biokemi; Medical Biochemistry; molekylärbiologi; Molecular Biology;

    Sammanfattning : In order to build any structure, a good supply of materials, accurate workers and quality control are needed. This is even the case when constructing DNA, the so-called “Code of Life.” For a species to continue to exist, this DNA code must be copied with incredibly high accuracy when each and every cell replicates. LÄS MER

  5. 24. dNTPs : the alphabet of life

    Författare :Dinesh Kumar; Andrei Chabes; Britt-Marie Sjöberg; Umeå universitet; []
    Nyckelord :ribonucleotide reductase; dNTP pools; s-phase checkpoint; mutagenesis; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : From microscopic bacteria to the giant whale, every single living organism on Earth uses the same language of life: DNA. Deoxyribonucleoside triphosphates––dNTPs (dATP, dTTP, dGTP, and dCTP)––are the building blocks of DNA and are therefore the “alphabet of life”. LÄS MER

  7. 25. Structural basis of cysteine biosynthesis and peptidoglycan remodelling in Mycobacterium tuberculosis

    Författare :Dominic Böth; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mycobacterium tuberculosis is the causative agent of tuberculosis, which is responsible for 1.3 million deaths annually. Treatment is difficult due to an elaborate defense machinery, which includes specific metabolic changes of the bacilli upon exposure to antibiotics and the immune response of the host. LÄS MER