Sökning: "genome integrity"
Visar resultat 6 - 10 av 60 avhandlingar innehållade orden genome integrity.
6. Array-based Genomic and Epigenomic Studies in Healthy Individuals and Endocrine Tumours
Sammanfattning : The human genome is a dynamic structure, recently recognized to present with significant large-scale structural variation. DNA-copy number changes represent one common type of such variation and is found both between individuals and within the somatic cells of the same individual, especially in disease states like cancer. LÄS MER
7. Biochemical analysis of Pfh1, the essential Pif1 family helicase in Schizosaccharomyces pombe
Sammanfattning : DNA stores the genetic information of all living organisms, and this information needs to be copied accurately and passed on to each daughter cell when a cell divides. However, the DNA replication machinery often meets obstacles in the genome that cause fork pausing and might result in DNA damage. LÄS MER
8. Insights into the roles of the essential Pfh1 DNA helicase in the nuclear and mitochondrial genomes
Sammanfattning : Eukaryotic cells have two sets of genomes, the nuclear and mitochondrial, and both need to be accurately maintained. Also, the rate of transcription must be precisely regulated in these genomes. However, there are many natural barriers that dysregulate these processes. LÄS MER
9. The interplay between chromosome structure and meiotic integrity
Sammanfattning : Sexually reproducing organisms employ a specialized cell division called meiosis to form unique, haploid gametes from a diploid precursor cell. Upon fertilization, two opposite-sex gametes fuse to create a zygote that will develop into the offspring. LÄS MER
10. DNA G-quadruplex structures in the mammalian genome : dissecting genome-wide mechanisms of formation and turnover of DNA G-quadruplexes
Sammanfattning : Since the beginning of 20th century, when the G-tetrad was first discovered, scientists have been seeking to understand the role of G4 quadruplex structures (G4s) in replication, DNA damage, telomere integrity and the regulation of gene expression. However, it is likely that the field has just scratched the tip of the iceberg when it comes to assessing and interpreting the function of individual G4s, forming in a specific locus, in the complex context of chromatin. LÄS MER