Sökning: "Hareth Nahi"

Hittade 1 avhandling innehållade orden Hareth Nahi.

1. 1. p53 guardian of the genome and target for improved treatment of leukemia

   Författare :Hareth Nahi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :p53; p14ARF; PRIMA; RITA; AML; CLL; HDM-2;

   Sammanfattning : P53 acts in several cellular processes as cell cycle checkpoints, DNA repair senescence and the surveillance of genomic integrity. Wt p53 inhibits cancer processes by causing cell cycle arrest and apoptosis. P53 is strongly regulated by the HDM-2 protein, which builds a complex with p53 leading to proteosomal degradation of p53. LÄS MER