Sökning: "foci"

Visar resultat 16 - 20 av 158 avhandlingar innehållade ordet foci.

  1. 16. Dissemination of Toxoplasma gondii to the central nervous system : with special reference to in vivo bioluminescence imaging

    Författare :Isabel Dellacasa Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Toxoplasma gondii causes an asymtomatic chronic infection in immune competent individuals that can be life-threatening in individuals that become immuno-compromised or to the developing fetus. This thesis aimed to (1) establish a novel murine model to study acute and reactivated toxoplasmosis in real-time using in vivo bioluminescence imaging (BLI), (2) investigate the migratory pathways utilized by Toxoplasma for systemic dissemination, especially to the central nervous system (CNS) and (3) address the role of resident brain glia cells in the setting of recrudescent infection in mice. LÄS MER

  3. 17. Early events of EBV mediated B cell transformation

    Författare :Katja Pokrovskaja; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :EBV; EBNA; p53; LMP-1; BL; GC; pNDCFs;

    Sammanfattning : Epstein-Barr virus (EBV) efficiently immortalizes B cells in vitro leading to the establishment of lymphoblastoid cell lines (LCLs). Genes encoding RB and p53 are frequently deleted or mutated in human tumors. EBV immortalized LCLs, however, retain both genes in their wild type state. LÄS MER

  4. 18. Clinical significance of immunohistochemistry in breast cancer diagnostics

    Författare :Slavica Janeva; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer biomarkers; immunohistochemistry; surrogate subtype; RT- qPCR; multifocal breast cancer; lymph node metastasis; triple-negative breast cancer; older women;

    Sammanfattning : For patients with breast cancer, modern patient-tailored treatment depends on tumor- specific characteristics, i.e., estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 (HER2), and the proliferation marker Ki67. LÄS MER

  5. 19. Assessing the ERG rearrangement for clinincal use in patients with prostrate cancer

    Författare :Maria Svensson; Ove Andrén; Swen-Olof Andersson; Fredrik Enlund; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; prognosis; biomarkers; ETS genes; ERG rearrangement; fluoroscence in situ hybridization; Medicine; Medicin;

    Sammanfattning : In Sweden, close to 10 000 men are annually diagnosed with prostate cancer (PCa) and approximately 2400 men die of their disease each year. Today there is no reliable marker that can separate patients who will have an aggressive type of disease that requires treatment, from patients who will have a more indolent clinical course and can be left untreated. LÄS MER

  7. 20. Focal atrial tachycardia : Insights concerning the arrhythmogenic substrate based on analysis of intracardiac electrograms and inflammatory markers

    Författare :Ioan Liuba; Gerhard Hindricks; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Background: Focal atrial tachycardias are tachycardias characterized by a radial spread of activation from a discrete area of the atrial myocardium. They account for 10-15% of supraventricular tachycardias and are generally poorly responsive to pharmacological treatment. The pathophysiologic substrate of these arrhythmias remains poorly understood. LÄS MER