Sökning: "foci"

Visar resultat 11 - 15 av 158 avhandlingar innehållade ordet foci.

  1. 11. Topographical study of intranuclear distribution and compartementalization of viral and cellular proteins

    Författare :Wei-Qin Jiang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nuclei of eukaryotic cells contain a number of specialized domains involved in DNA replication, transcription, pre-mRNA splicing and ribosome assembly. In addition to these structures, nuclear bodies of unknown function have been described. LÄS MER

  3. 12. Apoptosis, proliferation, and sex steroid receptors in endometrium and endometrial carcinoma

    Författare :Marju Dahmoun; Torbjörn Bäckström; Karin Boman; Stefan Cajander; Seija Grénman; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; estradiol; progesterone; steroid receptors; apoptosis; proliferation; endometrial carcinoma; Ki-67; p53; immunohistochemistry; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; medicin; Medicine;

    Sammanfattning : This thesis focuses on the involvement of apoptosis and proliferation in the mechanisms of menstruation and hormonal replacement therapy, HRT, as well as in the mechanisms of progesterone therapy in endometrial carcinoma. The aim of the first study was to investigate endometrium for 4 days before and for 2 days during menstruation. LÄS MER

  4. 13. Role of Non-Homologous End-Joining in Repair of Radiation-Induced DNA Double-Strand Breaks

    Författare :Karin Karlsson; Bo Stenerlöw; Jörgen Carlsson; Thomas Helleday; Uppsala universitet; []
    Nyckelord :Molecular biology; DNA damage; DNA repair; DSB; NHEJ; DNA-PK; ionising radiation; high-LET; heat-labile sites; PFGE; Molekylärbiologi;

    Sammanfattning : Efficient and correct repair of DNA damage, especially DNA double-strand breaks (DSBs), is vital for the survival of individual cells and organisms. Defects in the DNA repair may lead to cell death or genomic instability and development of cancer. LÄS MER

  5. 14. Modulation of nuclear receptor function by interacting proteins

    Författare :Waffa Osman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nuclear receptors are a family of transcription factors involved in many biological processes. They represent key potentials as therapeutic targets for several clinical conditions such as diabetes, obesity, cardiovascular disease and cancer, because their activity is modulated by small molecules. LÄS MER

  7. 15. Genetic and morphological studies of tumor heterogeneity, multifocality and outcome in locally advanced prostate cancer

    Författare :Anna Kristiansen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prostate cancer is a leading cause of mortality worldwide. Patients with locally advanced disease have a higher risk of relapse after treatment with curative intent. Examples of risk factors are seminal vesicle invasion (SVI) and lymph node metastases. However, not all patients with adverse pathology experience recurrence. LÄS MER