Sökning: "multifocal breast cancer"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden multifocal breast cancer.

  1. 1. Breast cancer : Multifocality, heterogeneity, and related genetic signatures

    Författare :Gyula Pekar; Dumanski Jan; Sapino Anna; Uppsala universitet; []
    Nyckelord :breast; breast cancer multifocality; molecular phenotypes; intertumoral heterogeneity; biobanking; gene copy number aberrations;

    Sammanfattning : Breast carcinoma often exhibits a complex subgross morphology and may occupy a large volume of the breast tissue and show unifocal, multifocal or diffuse growth patterns. Expression of estrogen- and progesterone receptors, HER2 overexpression, tumor grade, and proliferative activity allows us to classify breast carcinoma into molecular subgroups (Luminal A, Luminal B, HER2-type, triple negative, and basal-like). LÄS MER

  3. 2. Clinical significance of immunohistochemistry in breast cancer diagnostics

    Författare :Slavica Janeva; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer biomarkers; immunohistochemistry; surrogate subtype; RT- qPCR; multifocal breast cancer; lymph node metastasis; triple-negative breast cancer; older women;

    Sammanfattning : For patients with breast cancer, modern patient-tailored treatment depends on tumor- specific characteristics, i.e., estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 (HER2), and the proliferation marker Ki67. LÄS MER

  4. 3. DCIS of the breast : aspects on treatment and prognosis

    Författare :Charlotta Wadsten; Malin Sund; Fredrik Wärnberg; Marjut Leidenius; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Breast cancer is the most common cancer form and a leading cause of death in women worldwide. Ductal breast carcinoma in situ (DCIS) is characterized by a proliferation of malignant cells confined within the mammary ducts and is a potential precursor of invasive breast cancer. LÄS MER

  5. 4. Sentinel Node Biopsy in Breast Cancer : Clinical and Immunological Aspects

    Författare :Jana de Boniface; Leif Bergkvist; Annika Håkansson; Omgo Nieweg; Uppsala universitet; []
    Nyckelord :Surgery; breast cancer; tumour immunology; sentinel node biopsy; CD3-zeta; CD28; Kirurgi;

    Sammanfattning : The most important prognostic factor in breast cancer is the axillary lymph node status. The sentinel node biopsy (SNB) is reported to stage the axilla with an accuracy > 95 % in early breast cancer. Tumour-related perturbation of T-cell function has been observed in patients with malignancies, including breast cancer. LÄS MER

  7. 5. Sentinel Node in Clinical Practice : Implications for Breast Cancer Treatment and Prognosis

    Författare :Yvette Andersson; Leif Bergkvist; Jan Frisell; Jana de Boniface; Robert Mansel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; sentinel node; micrometastases; survival; non-sentinel node metastases;

    Sammanfattning : The introduction of sentinel lymph node biopsy (SLNB) has conveyed several new issues, such as the risk of false negativity, long-term consequences, the prognostic significance of micrometastases and whether ALND can be omitted in sentinel lymph node- (SLN) positive patients.Archived SLN specimens from 50 false negative patients and 107 true negative controls were serially sectioned and stained with immunohistochemistry. LÄS MER