Sökning: "farmaci farmaceutisk kemi"

Visar resultat 11 - 15 av 17 avhandlingar innehållade orden farmaci farmaceutisk kemi.

  1. 11. Antimicrobial Peptide Interactions with Phospholipid Membranes : Effects of Peptide and Lipid Composition on Membrane Adsorption and Disruption

    Författare :Adam A Strömstedt; Martin Malmsten; Georges Belfort; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antimicrobial; peptide; adsorption; liposome; membrane; melittin; cholesterol; tryptophan; phospholipid; bilayer; PHARMACY; FARMACI; Pharmaceutical Physical Chemistry; farmaceutisk fysikalisk kemi;

    Sammanfattning : The interactions between antimicrobial peptides and phospholipid membranes were investigated, in terms of lipid headgroup variations and the role of cholesterol, as well as peptide composition and structure. Also strategies for increasing proteolytic stability were evaluated. LÄS MER

  3. 12. Synthesis and structure activity relationships of competitive NMDA antagonists with analgesic activity

    Författare :Britt-Marie Swahn; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Sammanfattning : The compounds cis-3-(1-oxo-2-phosphonoethyl)-2-piperidinecarboxylic acid 1 and cis-3-(1-hydroxy-2-phosphonoethyl)-2-piperidinecarboxylic acid 2 were synthesized and found to be potent N-methyl-D-aspartate (NMDA) antagonists. NMR analysis showed that 1 prefers a 2eq,3ax chair conformation probably due to a conformer-stabilizing internal hydrogen bond. LÄS MER

  4. 13. Investigation of the Freeze-Thawing Process for Pharmaceutical Formulations of a Model Protein

    Författare :Anna Hillgren; Jörgen Tegenfeldt; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Physical and Inorganic Pharmaceutical Chemistry; fysikalisk och oorganisk farmaceutisk kemi;

    Sammanfattning : Recent advances in recombinant DNA technology have resulted in a great number of proteins with a potential to enter pharmaceutical formulations. The most commonly used method for preparing protein pharmaceuticals is by freeze-drying. LÄS MER

  5. 14. Electrochemical Methods for Drug Characterisation and Transdermal Delivery : Capillary Zone Electrophoresis, Conductometry, and Iontophoresis

    Författare :Nadia Merclin; Per Hansson; Sven Engström; Arto Urtti; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Capillary zone electrophoresis; precision conductometry; iontophoresis; passive diffusion; lidocaine; ALA; ALA-ester derivatives; sponge phase; carbopol gel; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : This thesis concerns the development and utilisation of techniques for characterisation and transdermal delivery of various systems for pharmaceutical applications.The degree of dissociation of drug molecules and the mobilities of the different species formed are essential factors affecting the rate of drug delivery by iontophoresis. LÄS MER

  7. 15. Interaction between Crosslinked Polyelectrolyte Gels and Oppositely Charged Surfactants

    Författare :Peter Nilsson; Per Hansson; Ksenija Kogej; Uppsala universitet; []
    Nyckelord :Pharmaceutical chemistry; gel; polyelectrolyte; surfactant; deswelling; kinetics; phase separation; volume transition; ion-exchange; diffusion; liquid crystal; SAXS; cubic Pm3n; Farmaceutisk kemi;

    Sammanfattning : The interactions between anionic, crosslinked gels and cationic surfactants have been investigated. When exposed to oppositely charged surfactant, the gel collapses into a dense complex of polyion and micelles. LÄS MER