Sökning: "Capillary zone electrophoresis"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden Capillary zone electrophoresis.

  1. 1. Separation of Proteins with Capillary Electrophoresis in Coated Capillaries with and without Electroosmosis : Studies on Zone Broadening and Analytical Performances

    Författare :Sheila Mohabbati; Douglas Westerlund; Bo Karlberg; Uppsala universitet; []
    Nyckelord :Pharmaceutical chemistry; Capillary electrophoresis; capillary coatings; proteins; zone broadening; zone sharpening; efficiency; resolution; protein-surface adsorption; protein-buffer interaction; analytical performance; Farmaceutisk kemi;

    Sammanfattning : Proteins have such structural features that they may interact with different types of surfaces by all possible forces, i.e., electrostatic, hydrogen bonding, hydrophobic. In this thesis two different types of coatings for fused silica capillaries aimed to eliminate such interactions have been studied. LÄS MER

  3. 2. Electrochemical Methods for Drug Characterisation and Transdermal Delivery : Capillary Zone Electrophoresis, Conductometry, and Iontophoresis

    Författare :Nadia Merclin; Per Hansson; Sven Engström; Arto Urtti; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Capillary zone electrophoresis; precision conductometry; iontophoresis; passive diffusion; lidocaine; ALA; ALA-ester derivatives; sponge phase; carbopol gel; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : This thesis concerns the development and utilisation of techniques for characterisation and transdermal delivery of various systems for pharmaceutical applications.The degree of dissociation of drug molecules and the mobilities of the different species formed are essential factors affecting the rate of drug delivery by iontophoresis. LÄS MER

  4. 3. Bioanalytical separation using capillary electrophoresis : Applications with microbubbles and proteins

    Författare :Leila Josefsson; Åsa Emmer; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Background electrolyte; capillary electrophoresis; contrast agents; electroosmotic flow; ethylammonium nitrate; ionic liquids; microbubbles; particles; polyvinyl alcohol microbubbles; and separation; Kemi; Chemistry;

    Sammanfattning : In this thesis the possibilities of using capillary electrophoresis as a separation technique for analysis of proteins and microbubbles is presented.A complete analytical process consists of five necessary steps of which one is the actual analysis step. For this step a suitable analytical technique is needed. LÄS MER

  5. 4. True Monoliths as Separation Media : Homogeneous Gels for Electrophoresis and Electrochromatography in the Capillary and Microchip Modes

    Författare :Ákos Végvári; Douglas Westerlund; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; capillary electrophoresis; capillary electrochromatography; gel electrophoresis; agarose; polyacrylamide; b-cyclodextrin; DNA; peptide; glutathione; drug enantiomers; microchip; Biokemi; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : The thesis focuses on the development of new homogeneous gels for the separation of drug enantiomers, peptides, DNA and virus by electrophoresis and electrochromatography in capillaries and microchips. This type of separation media offers high resolution and small zone broadening. LÄS MER

  7. 5. Separation of Pharmaceuticals by Capillary Electrophoresis using Partial Filling and Multiple-injections

    Författare :Henrik Lodén; Curt Pettersson; Torbjörn Arvidsson; Ahmad Amini; Morgan Stefansson; Uppsala universitet; []
    Nyckelord :Capillary Coating; Chiral Separation; Enantiomers; Mass-spectrometric Detection; Method Validation; Multiple-injection Capillary Zone Electrophoresis; Non-aqueous Capillary Electrophoresis; Organic Solvents; Pharmaceutical Analysis; Quantitative Analysis;

    Sammanfattning : Different multiple-injection methodologies and the partial filling technique (PFT) have been utilized for separation of pharmaceuticals by capillary elec-trophoresis. In multiple-injection capillary zone electrophoresis (MICZE), the samples and all standards, used for construction of the calibration curve, are analyzed within a single run. LÄS MER