Sökning: "bilayer"

Visar resultat 1 - 5 av 243 avhandlingar innehållade ordet bilayer.

  1. 1. Interaction Between Antimicrobial Peptides and Phospholipid Membranes : Effects of Peptide Length and Composition

    Författare :Lovisa Ringstad; Martin Malmsten; Per Hansson; Jeremy Ramsden; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adsorption; antibacterial; antimicrobial peptide; bilayer; ellipsometry; electrochemistry; electrostatic interactions; hydrophobicity; liposome; membrane; monolayer; phospholipid; secondary structure; supported bilayer.; PHARMACY; FARMACI; Pharmaceutical Physical Chemistry; farmaceutisk fysikalisk kemi;

    Sammanfattning : Due to increasing problems with bacterial resistance development, there is a growing need for identifying new types of antibiotics. Antimicrobial peptides constitute an interesting group of substances for this purpose, since they are believed to act mainly by disrupting the bacterial membrane, which is a fast and non-specific mechanism. LÄS MER

  2. 2. Nanosized Bilayer Disks as Model Membranes for Interaction Studies

    Författare :Anna Lundquist; Katarina Edwards; Marja-Liisa Riekkola; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Disk; disc; lipid bilayer; PEG-lipid; model membrane; interaction; partitioning; drug; liposome; cryo-TEM; neutron scattering; capillary electrophoresis; immobilization; biosensor; membrane protein; melittin; Chemistry; Kemi;

    Sammanfattning : PEG-lipid stabilized bilayer disks have been found in lipid mixtures containing polyethylene glycol (PEG)-lipids where the combination of a high bending rigidity and low PEG-lipid/lipid miscibility favours disk formation. The disks are planar and circular in shape and their long-term stability is excellent. LÄS MER

  3. 3. Drug Partitioning into Natural and Artificial Membranes : Data Applicable in Predictions of Drug Absorption

    Författare :Caroline Engvall; Birgitta Tomkinson; Katarina Edwards; Sven Engström; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Bilayer disk; Cholesterol; Drug partitioning; Drugs; Electrostatic effects; Immobilized liposome chromatography; Liposome; Membrane protein; Model membrane; Oligonucleotide-liposome complex; Phospholipid; Phospholipid bilayer; Proteoliposome; Surfactant; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : When drug molecules are passively absorbed through the cell membrane in the small intestine, the first key step is partitioning of the drug into the membrane. Partition data can therefore be used to predict drug absorption. LÄS MER

  4. 4. Partitioning of Drugs and Lignin Precursor Models into Artificial Membranes

    Författare :Elisabet Boija; Gunnar Johansson; Per Lundahl; Christine Lagerquist Hägglund; Marja-Liisa Riekkola; Uppsala universitet; []
    Nyckelord :Biochemistry; Bilayer disk; Capillary electrophoresis; Detergent; Drug; Electrostatic interaction; Hydrophobic interaction; Immobilized liposome chromatography; Lignin; Lignin precursor model; Liposome; Membrane model; Octanol water partitioning; Partitioning; Phospholipid; Phospholipid bilayer; Sterol; Biokemi;

    Sammanfattning : The main aim of this thesis was to characterize membrane-solute interactions using artificial membranes in immobilized liposome chromatography or capillary electrophoresis. The partitioning of a solute into a cell membrane is an essential step in diffusion across the membrane. LÄS MER

  5. 5. Interfacial Properties of Lipid Liquid Crystalline Nanoparticles

    Författare :Pauline Vandoolaeghe; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; interaction; adsorption; surface; peptide; bilayer; cubic phase; monoolein; cubosome; lipid; liquid crystalline nanoparticles; ellipsometry; neutron reflectivity; QCM-D; SAXD;

    Sammanfattning : Lipid liquid crystalline nanoparticles are studied for their potential as biocompatible carriers for pharmaceutical, food and cosmetic applications. Their potential as delivery vehicles is due to their nanometer size, their controllable structure and physical properties and their large carrying capacity of a wide range of molecules. LÄS MER