Sökning: "epigenetic dysregulation"
Visar resultat 6 - 10 av 19 avhandlingar innehållade orden epigenetic dysregulation.
6. Epigenetic and bioelectronic tools to study neural stem cells in health and disease
Sammanfattning : Brain development is a highly controlled, complex, and dynamic process. The mechanisms of its control need to accommodate the constantly changing contexts which, overtime, support the emergence of new neural structures and functions. LÄS MER
7. Exploring the role of epigenetic alterations in myeloid malignancies with focus on drug response
Sammanfattning : The production of blood cells (hematopoiesis), where the hematopoietic stem cell (HSC) is the cell of origin of all blood cells, is regulated by a complex network of intrinsic and extrinsic signals. Dysregulation of hematopoiesis, including somatic heterozygous mutations, cytogenetic aberrations, or epigenetic aberrations, are found in hematological malignancies. LÄS MER
8. FET fusion oncoproteins in sarcoma tumorigenesis - lnteractions with the SWI/SNF chromatin remodeling complex and epigenetic effects
Sammanfattning : The FET family of fusion oncoproteins containing the N-terminal of either FUS, EWSR1 or TAF15 together with a transcription factor partner is the characteristic oncogenic driver of more than 20 types of sarcoma and leukemia, including myxoid liposarcoma and Ewing sarcoma. The FET oncoproteins are thought to function as aberrant transcription factors, however, the exact oncogenic mechanism remains to be elucidated. LÄS MER
9. How can an organism´s life experience affect their descendants? Insights from epigenetic and transgenerational effects of chemical exposure in zebrafish
Sammanfattning : Environmental pollution causes approx. 10% of human diseases, and some develop in the progeny because of parental exposure. Effects passed on to subsequent generations may be a consequence of genetic mutations, or of inherited changes in epigenetic patterns. LÄS MER
10. The Human Pancreatic Islet Methylome and Its Role in Type 2 Diabetes
Sammanfattning : Islet dysfunction is central to the development and progression of type 2 diabetes (T2D). Epigenetic modifications are essential for establishing and maintaining cell identity and function in normal circumstances. Exposure to adverse environmental factors may alter the epigenome, and result in changes of gene expression and the resulting phenotype. LÄS MER