Sökning: "Joëlle Rüegg"

Hittade 4 avhandlingar innehållade orden Joëlle Rüegg.

  1. 1. How can an organism´s life experience affect their descendants? Insights from epigenetic and transgenerational effects of chemical exposure in zebrafish

    Författare :Mélanie Blanc; Steffen Keiter; Joëlle Rüegg; Xavier Cousin; Nikolai Scherbak; Michael K. Skinner; Örebro universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Neurotoxicity; behavior; RNA-Seq; RRBS; TEI; permethrin; PCBs; PBDEs; coumarin 47;

    Sammanfattning : Environmental pollution causes approx. 10% of human diseases, and some develop in the progeny because of parental exposure. Effects passed on to subsequent generations may be a consequence of genetic mutations, or of inherited changes in epigenetic patterns. LÄS MER

  3. 2. Novel Endpoints To Unravel Developmental Neurotoxicity : From DNA methylation responses to methylmercury to the in vitro identification of endocrine disruptors

    Författare :Andrea Cediel-Ulloa; Joëlle Rüegg; Pamela J. Lein; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Developmental neurotoxicity; Methylmercury; DNA methylation; Endocrine disruptors; in vitro assay development; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

    Sammanfattning : The developing brain is especially sensitive to environmental stressors due to its dependence on the precise spatiotemporal regulation of multiple signals, and the long time period required for its formation. Some chemicals can interfere with molecular and cellular processes driving brain development, including epigenetic processes such as DNA methylation. LÄS MER

  4. 3. Estrogen signaling in colon inflammation and colorectal cancer

    Författare :Linnea Hases; Cecilia Williams; Joëlle Rüegg; KTH; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical Technology; Medicinsk teknologi;

    Sammanfattning : Colorectal cancer (CRC) is the third most deadly form of cancer in the Western world. Although screening efforts have reduced the overall mortality, the incidence is increasing among young adults. LÄS MER

  5. 4. Impact of epidemiologically identified mixtures of endocrine disrupting chemicals on metabolic programming

    Författare :Polina Lizunkova; Joëlle Rüegg; Elin Engdahl; Joachim Sturve; Carl-Gustaf Bornehag; Juliette Legler; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Endocrine disrupting chemicals; Mixtures; Metabolism; Developmental Toxicology; Epigenetics; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Sammanfattning : We are ubiquitously exposed to a plethora of endocrine-disrupting chemicals (EDCs), i.e. substances that alter the function(s) of the endocrine system. While ample evidence show individual EDC's influence on developmental processes resulting in adverse health outcomes, less is known about the effects of human-relevant EDC mixtures exposure. LÄS MER