Sökning: "Myxoid liposarcoma"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Myxoid liposarcoma.

  1. 1. Molecular studies of genetic changes in myxoid and round cell liposarcoma

    Författare :Sofia Järnum; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; Cytologi; onkologi; cancer; Medicine human and vertebrates ; Medicin människa och djur ; oncology; Cytology; autocrine loop; RDA; persephin; RET; LEPREL1; translocation; fusion gene; liposarcoma; TLS; CHOP;

    Sammanfattning : Chromosomal translocations commonly result in the production of fusion genes and the fusion genes are often tumor-type specific. In myxoid and round cell liposarcomas (MLS/RCLS), almost 95% of the cases carry a t(12;16)(q13;p11). In the remaining 5% of the MLS/RCLS tumors, another translocation and fusion gene can be found, i.e. LÄS MER

  3. 2. Clinical and molecular studies of liposarcoma

    Författare :Katarina Engström; Göteborgs universitet; []
    Nyckelord :Liposarcoma; radiotherapy; prognostic factors; transfection; FUD-DDIT3; adipogenesis; microarray expression analysis; cell cycle; immunohistochemistry;

    Sammanfattning : Aims: (1) To analyse clinicopathological characteristics, treatment and outcome of liposarcoma, and to determine whether, and how, the Scandinavian Sarcoma Group (SSG) treatment guidelines were followed; (2) to analyse tumour volume and morphology response after radiotherapy in myxoid/round cell liposarcoma (MLS/RCLS); (3) to examine the role of the MLS-specific fusion gene FUS-DDIT3 in development of liposarcomas; and (4) to analyse expression patterns of cell cycle regulating proteins in MLS. Methods: (1) A total of 319 liposarcomas reported between 1986?1998 to the SSG Register were reviewed. LÄS MER

  4. 3. The role of fusion oncogenes and cancer stem cells in myxoid liposarcoma

    Författare :Soheila Dolatabadi; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FUS; FUS-DDIT3; myxoid liposarcoma; cancer stem cells; JAK-STAT;

    Sammanfattning : Myxoid liposarcoma (MLS) is characterised by the FUS-DDIT3, or the less common EWSR1-DDIT3 fusion oncogene and is the second most common type of liposarcoma. The fusion oncogenes encode chimeric transcription factors that are causal factors in tumourigenesis however, their functions are poorly known. LÄS MER

  5. 4. Liposarcomas - proliferation, senescence and the role of DDIT3

    Författare :Christina Kåbjörn-Gustafsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Liposarcoma; FUS-DDIT3; TP53; senescence;

    Sammanfattning : Lipomatous tumors comprise benign and malignant forms called lipomas and liposarcomas. Myxoid/round cell liposarcoma (MLS/RCLS) is the second most common liposarcoma and is characterized by the fusion oncogenes FUS-DDIT3 or EWSR1-DDIT3. LÄS MER

  7. 5. FET proteins in cancer and development

    Författare :Mattias K Andersson; Göteborgs universitet; []
    Nyckelord :FUS; EWS; TAF15; FUS-DDIT3; myxoid liposarcoma; NF-κB; NFKBIZ; FLT1; CDK2;

    Sammanfattning : Chromosomal translocations leading to rearrangements of FET family genes (FUS, EWSR1 and TAF15) are found in numerous human cancers. These genetic alterations result in the formation of fusion oncogenes that express potent chimeric oncoproteins able to promote tumor development. LÄS MER