Sökning: "endocrine disruption"

Visar resultat 41 - 45 av 47 avhandlingar innehållade orden endocrine disruption.

1. 41. Exploring functional subsets of cancer-associated fibroblasts

   Författare :Michael Bartoschek; Avdelningen för translationell cancerforskning; []
   Nyckelord :;

   Sammanfattning : The tumor microenvironment consists of several interacting cell types. Cancer research focssed mainly on the malignant cell in the past. The importance of the tumor microenvironment is increasingly appreciated, as endothelial cells and immune cells were identified as targets for anti-tumor therapy. LÄS MER

3. 42. Functional role of a constitutively active dioxin/Ah receptor in a transgenic mouse model

   Författare :Patrik Andersson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Dioxin Ah receptor; TCDD; dioxin; stomach tumor; osteopontin; peritoneal B1 B cells; transcription factor; gene expression;

   Sammanfattning : The dioxin/ Aryl hydrocarbon receptor is a ligand-activated transcription factor that mediates most (if not all) of the toxic effects of the group of highly potent environmental pollutants collectively called dioxins and PCBs, including the highly toxic compound 2,3,7,8tetrachlorodibenzo-p-dioxin (TCDD). The toxic effects include immune suppression, endocrine disruption, impaired reproduction and carcinogenesis. LÄS MER

4. 43. Microplastics in the aquatic environment: Insights into biological fate and effects in fish

   Författare :Giedrė Ašmonaitė; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; microplastics; nanoplastics; plastic pollution; effects; fish; chemical mixtures; ecotoxicology;

   Sammanfattning : According to the United Nations, plastic pollution in the natural environment has been identified as one of the biggest environmental challenges of this century and has become a cause for an emerging international concern. It has been predicted that up to 12 million tons of plastic waste reach the aquatic environment annually. LÄS MER

5. 44. VEGF-mediated vascular functions in health and disease

   Författare :Ziquan Cao; Eric Wahlberg; Yihai Cao; Toste Länne; Kayoko Hosaka; Jack L. Arbiser; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Angiogenesis is essential for physiological processes including embryonic development, tissue regeneration, and reproduction. Under various pathological conditions the same angiogenic process contribute to the onset, development, and progression of many human diseases including cancer, diabetic complications, ocular disease, chronic inflammation and cardiovascular disease. LÄS MER

7. 45. What contributes to human body burdens of phthalate esters? : An experimental approach

   Författare :Georgios Giovanoulis; Cynthia A. de Wit; Jörgen Magnér; Brice Appenzeller; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phthalates; Alternative plasticizers; DINCH; In vivo screening; Urine; Nails; Air; Dust; Hand wipes; Duplicate diet; Predictors of exposure; Applied Environmental Science; tillämpad miljövetenskap;

   Sammanfattning : Phthalate esters (PEs) and alternative plasticizers used as additives in numerous consumer products are continuously released into the environment leading to subsequent human exposure. The ubiquitous presence and potential adverse health effects (e.g. LÄS MER