Sökning: "dual topology"

Visar resultat 1 - 5 av 26 avhandlingar innehållade orden dual topology.

1. 1. The Ins and Outs of Membrane Proteins : Topology Studies of Bacterial Membrane Proteins

   Författare :Mikaela Rapp; Gunnar von Heijne; Christopher Tate; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; membrane protein; topology; dual topology; Biochemistry; Biokemi;

   Sammanfattning : α-helical membrane proteins comprise about a quarter of all proteins in a cell and carry out a wide variety of essential cellular functions. This thesis is focused on topology analyses of bacterial membrane proteins. The topology describes the two-dimensional structural arrangement of a protein relative to the membrane. LÄS MER

3. 2. Dual-topology membrane proteins in Escherichia coli

   Författare :Susanna Seppälä; Gunnar von Heijne; Dirk Jan Slotboom; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane protein topology; dual-topology; evolution; Escherichia coli; Biochemistry; biokemi;

   Sammanfattning : Cellular life, as we know it, is absolutely dependent on biological membranes; remarkable superstructures made of lipids and proteins. For example, all living cells are surrounded by at least one membrane that protects the cell and holds it together. LÄS MER

4. 3. Topology optimization of antennas and waveguide transitions

   Författare :Emadeldeen Hassan; Martin Berggren; Daniel Noreland; Eddie Wadbro; Mats Gustafsson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Maxwell s equations; topology optimization; antennas; waveguide transition; finite-difference time-domain; gradient-based optimization; adjoint-field problem; microwave devices.; business data processing; administrativ databehandling;

   Sammanfattning : This thesis introduces a topology optimization approach to design, from scratch, efficient microwave devices, such as antennas and waveguide transitions. The design of these devices is formulated as a general optimization problem that aims to build the whole layout of the device in order to extremize a chosen objective function. LÄS MER

5. 4. EmrE, a puzzling transporter : Assembly, biogenesis and evolution of a dual-topology membrane protein

   Författare :Pilar Lloris-Garcerá; Gunnar von Heijne; Da-Neng Wang; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; biokemi;

   Sammanfattning : Biological membranes are the key to cell existence, as they are able to both isolate and connect their interior with the environment. Membranes are composed of lipids and proteins that create a semi-permeable barrier; because the lipid bilayer stops free diffusion of most molecules and ions, membrane proteins play an important role in connecting the interior of the cell with its environment. LÄS MER

7. 5. Topology and membrane rearrangements of the hepatitis C virus protein NS4B

   Författare :Marika Lundin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Hepatitis C virus; NS4B; NS5A; topology; posttranslational translocation membrane rearrangements; endoplasmic reticulum; polyprotein; membrane protein; membrane associated foci; oligomerization; viral replication; replicon; replication complex; mutations; immunoprecipitation;

   Sammanfattning : Hepatitis C virus (HCV) is a major cause of chronic liver disease and viral hepatitis around the world. Approximately 180 million people or 3% of the world's population are infected with the virus. LÄS MER