Sökning: "membrane associated foci"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden membrane associated foci.

  1. 1. Topology and membrane rearrangements of the hepatitis C virus protein NS4B

    Författare :Marika Lundin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hepatitis C virus; NS4B; NS5A; topology; posttranslational translocation membrane rearrangements; endoplasmic reticulum; polyprotein; membrane protein; membrane associated foci; oligomerization; viral replication; replicon; replication complex; mutations; immunoprecipitation;

    Sammanfattning : Hepatitis C virus (HCV) is a major cause of chronic liver disease and viral hepatitis around the world. Approximately 180 million people or 3% of the world's population are infected with the virus. LÄS MER

  3. 2. Molecular studies of the hepatitis C virus : the role of IRES activity for therapy response, and the impact of the non-structural protein

    Författare :Hannah Kim Lindström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hepatitis C virus; IRES; viral translation; dual luciferase assay; therapy response; NS4B; topology; membrane rearrangements; membrane associated foci; Immunofluorescence; oligomerization; viral replication; bi-cistronic subgenomic replicon; replicon complex; mutations;

    Sammanfattning : Chronic hepatitis C can lead to life threatening conditions like cirrhosis, liver failure and hepatocellular carcinoma. There are an estimated 170 million chronic carriers of the hepatitis C virus (HCV) world wide, making it a serious global health problem. LÄS MER

  4. 3. Effects of reactive oxygen species on the cellular vacuolar apparatus

    Författare :Johann Zdolsek; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Sammanfattning : Reactive and potentially harmful oxygen species occur, and are continuously formed, in all cells of a living organism. Increased production of these metabolites are seen in a number of pathological states, for instance in inflammatory foci or during reoxygenation of ischemic tissue. LÄS MER

  5. 4. Emerging roles of PFKFB3 and CX3CR1 in the DNA damage response and their potential as therapeutic targets in cancer

    Författare :Anna Huguet Ninou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Genomic instability in cancer is exploited therapeutically using DNA damaging therapies that cause irreparable lesions above the threshold of tolerable DNA damage levels. Nevertheless, toxic side effects on healthy tissues limit the therapeutic potential of such therapies. LÄS MER

  7. 5. Determination of biomarkers for lipid peroxidation and oxidative stress : Development of analytical techniques and methods

    Författare :Kristina Claeson Bohnstedt; Bo Karlberg; Niels Heegaard; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; capillary electrophoresis; mass spectrometry; electrospray; porous graphitic carbon; oxidative stress; lipid peroxidation; biomarker; malondialdehyde; hydroxynonenal; isoprostane; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Oxidative stress can be defined as a state of disturbance in the pro-oxidant/antioxidant balance in favour of the former, leading to potential damage. Processes associated with oxidative stress involve reactive oxygen species and radicals and can result in elevated levels of oxidatively modified or toxic molecules that can cause cellular malfunction, and even cell death. LÄS MER