Sökning: "membrane protein topology"

Visar resultat 1 - 5 av 56 avhandlingar innehållade orden membrane protein topology.

  1. 1. The Ins and Outs of Membrane Proteins Topology Studies of Bacterial Membrane Proteins

    Detta är en avhandling från Stockholm : Institutionen för biokemi och biofysik

    Författare :Mikaela Rapp; Gunnar von Heijne; Christopher Tate; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; membrane protein; topology; dual topology; ODONTOLOGY Biochemistry; ODONTOLOGI Biokemi;

    Sammanfattning : α-helical membrane proteins comprise about a quarter of all proteins in a cell and carry out a wide variety of essential cellular functions. This thesis is focused on topology analyses of bacterial membrane proteins. The topology describes the two-dimensional structural arrangement of a protein relative to the membrane. LÄS MER

  2. 2. Engineering membrane proteins for production and topology

    Detta är en avhandling från Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Författare :Stephen Toddo; Daniel Daley; Roslyn Bill; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Membrane protein; Over-expression; Protein production; Codon optimization; Escherichia coli; AraH; NarK; mRNA secondary structure; coding sequence; ribosome binding site; RBS; topology; split-GFP; biokemi; Biochemistry;

    Sammanfattning : The genomes of diverse organisms are predicted to contain 20 – 30% membrane protein encoding genes and more than half of all therapeutics target membrane proteins. However, only 2% of crystal structures deposited in the protein data bank represent integral membrane proteins. LÄS MER

  3. 3. Determinants of membrane protein topology

    Detta är en avhandling från Stockholm : Stockholm University

    Författare :Marie Johansson; Collin Robinson; [1999]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

    Sammanfattning : The living cell, no matter if it is a simple prokaryotic bacterial cell or a highly specialised eukaryotic cell, synthesises a vast number of different proteins. In most organisms, 20-30 % of all proteins are thought to be transmembrane integral membrane proteins. LÄS MER

  4. 4. Sequence-based predictions of membrane-protein topology, homology and insertion

    Detta är en avhandling från Stockholm : Institutionen för biokemi och biofysik

    Författare :Andreas Bernsel; Gunnar von Heijne; Volkhard Helms; ; [2008]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane protein; topology prediction; hidden markov model; homology detection; Sec translocon; NATURAL SCIENCES Chemistry Theoretical chemistry Bioinformatics; NATURVETENSKAP Kemi Teoretisk kemi Bioinformatik; Biochemistry; biokemi;

    Sammanfattning : Membrane proteins comprise around 20-30% of a typical proteome and play crucial roles in a wide variety of biochemical pathways. Apart from their general biological significance, membrane proteins are of particular interest to the pharmaceutical industry, being targets for more than half of all available drugs. LÄS MER

  5. 5. Exploring the Interplay of Lipids and Membrane Proteins

    Detta är en avhandling från Stockholm : Institutionen för biokemi och biofysik

    Författare :Candan Ariöz; Åke Wieslander; Daniel O. Daley; Malcolm East; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Membrane lipids; membrane proteins; anionic lipids; membrane remodeling; intracellular vesicles; model membrane systems; glycosyltransferase; Escherichia coli; lipid composition; fatty acid modification; membrane curvature; bacterial homeoviscous adaptation; biokemi; Biochemistry;

    Sammanfattning : The interplay between lipids and membrane proteins is known to affect membrane protein topology and thus have significant effect (control) on their functions. In this PhD thesis, the influence of lipids on the membrane protein function was studied using three different membrane protein models. LÄS MER