Sökning: "dual-topology"

Hittade 5 avhandlingar innehållade ordet dual-topology.

  1. 1. Dual-topology membrane proteins in Escherichia coli

    Författare :Susanna Seppälä; Gunnar von Heijne; Dirk Jan Slotboom; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane protein topology; dual-topology; evolution; Escherichia coli; Biochemistry; biokemi;

    Sammanfattning : Cellular life, as we know it, is absolutely dependent on biological membranes; remarkable superstructures made of lipids and proteins. For example, all living cells are surrounded by at least one membrane that protects the cell and holds it together. LÄS MER

  3. 2. EmrE, a puzzling transporter : Assembly, biogenesis and evolution of a dual-topology membrane protein

    Författare :Pilar Lloris-Garcerá; Gunnar von Heijne; Da-Neng Wang; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; biokemi;

    Sammanfattning : Biological membranes are the key to cell existence, as they are able to both isolate and connect their interior with the environment. Membranes are composed of lipids and proteins that create a semi-permeable barrier; because the lipid bilayer stops free diffusion of most molecules and ions, membrane proteins play an important role in connecting the interior of the cell with its environment. LÄS MER

  4. 3. The Ins and Outs of Membrane Proteins : Topology Studies of Bacterial Membrane Proteins

    Författare :Mikaela Rapp; Gunnar von Heijne; Christopher Tate; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; membrane protein; topology; dual topology; Biochemistry; Biokemi;

    Sammanfattning : α-helical membrane proteins comprise about a quarter of all proteins in a cell and carry out a wide variety of essential cellular functions. This thesis is focused on topology analyses of bacterial membrane proteins. The topology describes the two-dimensional structural arrangement of a protein relative to the membrane. LÄS MER

  5. 4. Structure, prediction, evolution and genome wide studies of membrane proteins

    Författare :Erik Granseth; Arne Elofsson; Gunnar von Heijne; Mark Sansom; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Theoretical chemistry; Teoretisk kemi; biokemi; Biochemistry;

    Sammanfattning : α-helical membrane proteins constitute 20-30% of all proteins in a cell and are involved in many essential cellular functions. The structure is only known for a few hundred of them, which makes structural models important. LÄS MER

  7. 5. Topology and membrane rearrangements of the hepatitis C virus protein NS4B

    Författare :Marika Lundin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hepatitis C virus; NS4B; NS5A; topology; posttranslational translocation membrane rearrangements; endoplasmic reticulum; polyprotein; membrane protein; membrane associated foci; oligomerization; viral replication; replicon; replication complex; mutations; immunoprecipitation;

    Sammanfattning : Hepatitis C virus (HCV) is a major cause of chronic liver disease and viral hepatitis around the world. Approximately 180 million people or 3% of the world's population are infected with the virus. LÄS MER