Sökning: "dopamine D 2 receptors"

Visar resultat 6 - 10 av 14 avhandlingar innehållade orden dopamine D 2 receptors.

1. 6. Physiopathological aspects of NMDA transmission in the basal ganglia : in vitro and in vivo release studies

   Författare :Michele Morari; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :basal ganglia; NMDA; dizocilpine; microdialysis; slices; synaptosomes; dopamine; acetylcholine; glutamate; GABA; 6OH-dopamine;

   Sammanfattning : N-methyl-D-aspartic acid (NMDA) is an excitatory amino acid selectively acting on a subclass of glutamate receptors (the NMDA ionotropic receptor) which has been involved in many of the physiological and pathological effects of glutamate in the CNS. The basal ganglia are particularly enriched in NMDA receptors and NMDA receptor activation in the basal ganglia has been involved in the expression of motor behaviour. LÄS MER

3. 7. Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs

   Författare :Kerstin Håkansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adenosine A2A receptor; basal ganglia; cAMP-dependent protein kinase; clozapine; DARPP-32; dopamine D 2 receptor; extracellular signal-regulated protein kinases 1 and 2; extrapyramidal side effects; glutamate AMPA receptor; haloperidol; knockout mouse; phosphorylation; schizophrenia; tyrosine hydroxylase.;

   Sammanfattning : The only effective therapy for schizophrenia is based on the use of antipsychotic drugs. These substances act as dopamine D 2 receptor antagonists and can be classified as typical or atypical. Typical antipsychotics, e.g. LÄS MER

4. 8. On the mechanisms of action of atypical antipsychotic drugs : an experimental study

   Författare :Peter Hertel; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :antipsychotic drugs; dopamine; serotonin; medial prefrontal cortex; dorsal raphe nucleus; risperidone; clozapine; idazoxan; [alpha]2 adrenoceptors; conditioned avoidance; catalepsy;

   Sammanfattning : A majority of schizophrenic patients respond to classical neuroleptic drugs which are believed to act largely via blockade of dopamine (DA) D2 receptors in limbic structures. However, a significant proportion do not respond to conventional D2 receptor blocking drugs or show a rather incomplete therapeutic effect, particularly on negative and cognitive symptoms. LÄS MER

5. 9. Characterization of neuropeptide, monoamine, and amino acid release in the basal ganglia of the rat : neuronal dependence and reciprocal interactions

   Författare :Zhi-Bing You; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :amino acids cholecystokinin dopamine dynorphin microdialysis morphineneostriatum rat substantia nigra.;

   Sammanfattning : Functional interactions in the basal ganglia of rats were characterized with in vivomicrodialysis. The study was mainly focused on the dynorphin and cholecystokinin (CCK) systems. The extracellular levels of both dynorphin B and CCK were found in the pM range inthe neostriatum and substantia nigra under basal conditions. LÄS MER

7. 10. Novel mechanism of action of antipsychotic drugs : effects on neuropeptides in rat brain

   Författare :Susanne H M Gruber; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Schizophrenia; D-amphetamine; Antipsychotic drugs; Neurotensin; Neuropeptide Y; Rat brain; Microdialysis;

   Sammanfattning : Schizophrenic patients have been reported to have lower concentrations of neurotensin (NT)-like immunoreactivity (-LI) in their cerebrospinal fluid (CSF) that normalize after treatment with antipsychotic drugs. Schizophrenic patients also had higher CSF concentrations of neuropeptide Y (NPY)-LI compared to controls, thus involvement of NPY in the disease has also been suggested. LÄS MER