Sökning: "conditioned avoidance"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden conditioned avoidance.

  1. 1. On the mechanisms of action of atypical antipsychotic drugs : an experimental study

    Författare :Peter Hertel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :antipsychotic drugs; dopamine; serotonin; medial prefrontal cortex; dorsal raphe nucleus; risperidone; clozapine; idazoxan; [alpha]2 adrenoceptors; conditioned avoidance; catalepsy;

    Sammanfattning : A majority of schizophrenic patients respond to classical neuroleptic drugs which are believed to act largely via blockade of dopamine (DA) D2 receptors in limbic structures. However, a significant proportion do not respond to conventional D2 receptor blocking drugs or show a rather incomplete therapeutic effect, particularly on negative and cognitive symptoms. LÄS MER

  3. 2. Finding improved drug strategies for schizophrenia : Preclinical studies on lumateperone and sodium nitroprusside

    Författare :Joep Titulaer; Åsa Konradsson-Geuken; Anne-Lie Svensson; Erika Roman; Kent Jardemark; Joshua Beckmann; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; schizophrenia; lumateperone; sodium nitroprusside; antipsychotic drugs; Farmaceutisk vetenskap; Pharmaceutical Science; Pharmacology; Farmakologi; Psychiatry; Psykiatri;

    Sammanfattning : Schizophrenia is a severe psychiatric disorder affecting approximately 20 million people worldwide. The disease consists of positive symptoms e.g. hallucinations, negative symptoms such as anhedonia, and cognitive deficits, e. LÄS MER

  4. 3. Automated behavioral phenotyping of inbred mouse strains and mouse models of Alzheimer disease

    Författare :Alina Codita; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Behavioral characterization of various mouse strains created as models for human diseases such as Alzheimer disease requires robust phenotyping methods. Previous work on inbred mouse strains has shown that some of the widely used behavioral methods yield inconsistent results across laboratories, in spite of standardization efforts. LÄS MER

  5. 4. Ghrelin in feeding: new insights into its role and the neurocircuits involved

    Författare :Marie Le May; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ghrelin; feeding; supramammillary nucleus; parabrachial nucleus;

    Sammanfattning : Appetite, originally evolved to ensure we consume enough of diverse nutrients to survive famines, has lost its survival advantage in our modern society, where food is plentiful. The hedonic aspect of appetite can indeed induce over-consumption of food, a major cause for the obesity pandemic. LÄS MER

  7. 5. The phencyclidine model of schizophrenia : dysregulation of brain dopamine systems induced by NMDA receptor antagonists

    Författare :Jan M Mathé; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :phencyclidine; MK-801; CNQX; prazosin; tetrodotoxin; dopamine; neurotensin; ventral tegmental area; nucleus accumbens; medial prefrontal cortex;

    Sammanfattning : Non-competitive NMDA receptor antagonists, such as phencyclidine (PCP) and dizocilpine (MK-801) can even acutely induce a drug induced psychotic state which closely resembles schizophrenia. The midbrain dopamine (DA) neurons, which originate in the ventral tegmental area (VTA), are involved in motivational, attentional and cognitive processes, and have also been profoundly implicated in schizophrenia. LÄS MER