Sökning: "Antipsychotic drugs"

Visar resultat 1 - 5 av 47 avhandlingar innehållade orden Antipsychotic drugs.

1. 1. Influence of antipsychotic drugs on hormone levels

   Författare :Kristina Melkersson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :antipsychotic agents; prolactin; growth hormone; insulin-like growth factor 1; insulin; leptin; lipids; side effects; weight gain; metabolic syndrome;

   Sammanfattning : The aim of the studies summarized in this thesis was to investigate the influence of antipsychotic drugs on hormone levels, in order to identify causes of hormonally related side effects of these drugs. The effect of antipsychotics on the prolactin (PRL) secretion, the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis and the glucose-insulin homeostasis was studied. LÄS MER

3. 2. Finding improved drug strategies for schizophrenia : Preclinical studies on lumateperone and sodium nitroprusside

   Författare :Joep Titulaer; Åsa Konradsson-Geuken; Anne-Lie Svensson; Erika Roman; Kent Jardemark; Joshua Beckmann; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; schizophrenia; lumateperone; sodium nitroprusside; antipsychotic drugs; Farmaceutisk vetenskap; Pharmaceutical Science; Pharmacology; Farmakologi; Psychiatry; Psykiatri;

   Sammanfattning : Schizophrenia is a severe psychiatric disorder affecting approximately 20 million people worldwide. The disease consists of positive symptoms e.g. hallucinations, negative symptoms such as anhedonia, and cognitive deficits, e. LÄS MER

4. 3. Modulation of prefrontal glutamatergic transmission and 'atypicality' of antipsychotic drugs

   Författare :Åsa Konradsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The glutamate hypothesis of schizophrenia suggests a relationship between hypoactive NMDA receptor-mediated glutamatergic transmission and the pathophysiology of schizophrenia. Previous results have demonstrated that atypical (e.g. clozapine, risperidone, and olanzapine), but not typical (e. LÄS MER

5. 4. Long-Term Functional Psychosis : Epidemiology in Two Different Counties in Sweden

   Författare :Birgitta Widerlöv; Lars von Knorring; Jerker Hetta; Uppsala universitet; []
   Nyckelord :Psychiatry; epidemiology; functional psychosis; schizophrenia; prevalence; rural-urban gradient; comparative study; antipsychotic drugs; diagnostic criteria; mortality; Psykiatri;

   Sammanfattning : This thesis is based on two independent studies, the first in Stockholm County (index year 1984; n=302), and the second, a replication and validation study, in Uppsala County (index year 1991; n=455).The general aim was to study all individuals with Long-term Functional Psychosis (LFP) within the two counties of Sweden from an epidemiological perspective and to perform specific studies on a subgroup of individuals with schizophrenia. LÄS MER

7. 5. Pharmaceutical And Immunollogical Challenge Of Fungal Pathogens

   Författare :Marios Stylianou; Constantin F. Urban; Christophe d' Enfert; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mast cells; Candida albicans; yeast to hyphal form; antifungal drugs; repurposed drugs; HTS;

   Sammanfattning : Incidences of fungal infections are on the rise in immunosuppressed people. Predominant causative agents for these mycoses are species of the genus Candida, including Candida albicans, Candida glabrata and Candida dublieniensis. Despite a wide range of emerging pathogens, C. albicans remains the leading cause. LÄS MER