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Visar resultat 1 - 5 av 14 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Pet imaging of two monoaminergic neurotransmitter systems in brain : studies of the norepinephrine transporter and dopamine D[2] receptor

    Författare :Nicholas Seneca; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Positron emission tomography (PET) has been widely used to study non-invasively function of the brain, pathophysiology of disease and aid in the development of new drugs. PET and selective radiolabeled molecules allow imaging of certain critical components of neurotransmission, such as pre-synaptic transporters and post-synaptic receptors in living brain. LÄS MER

  3. 2. Clozapine as a dopamine D₁ receptor agonist

    Författare :Peter Salmi; Leif Lindström; Stockholms universitet; []
    Nyckelord :psykologi; Psychology;

    Sammanfattning : Objectives'. The present study had two major objectives; [1] to examine the specific role of dopamine D, and DM receptors in body temperature regulation in rats, and [2] to examine in vivo dopamine D, and Dm receptor agonist/antagonist properties of clozapine by use of core temperature measurements.Methods'. LÄS MER

  4. 3. Perinatal asphyxia in the rat : a morphological and functional analysis of the dopamine systems and dopamine-mediated behaviours in a novel experimental model

    Författare :Yong Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Rat; Perinatal asphyxia; Dopamine; Noradrenaline; Dopamine receptors; Substantia nigra; Ventral tegmental area; Striatum; Accumbens nucleus; Locomotor activity; Attention disorders; bFGF; Fos; pH; pyruvate; lactate; glutamate; aspartate.;

    Sammanfattning : Asphyxia during labour in the human being is one of the important paediatric complications which can lead to various degree of injuries in the central nervous system. No efficient therapy is available at present. LÄS MER

  5. 4. DARPP-32 in the striatum : multiple regulation and physiological role

    Författare :Maria Lindskog; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DARPP-32; striatum; adenosine A 2A receptors; dopamine D; receptors; dopamine D 2 receptors; opioid receptors; cAMP; protein phosphorylation; behaviour;

    Sammanfattning : Protein phosphorylation is an important mechanism involved in intracellular signal transduction. The activity of many proteins is affected by their state of phosphorylation, which in turn is determined by the combined activities of protein kinases and protein phosphatases. LÄS MER

  7. 5. Synaptic transmission and synaptic plasticity in the mouse striatum

    Författare :Sietske Schotanus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The striatum is the major input nucleus of the basal ganglia and can be subdivided into a dorsal part and a ventral part that is also named nucleus accumbens (NAc). The dorsal part is involved in motor control and habit learning whereas the ventral part is mostly associated with rewardmotivated behaviors. LÄS MER