Sökning: "coreceptor"
Visar resultat 21 - 25 av 35 avhandlingar innehållade ordet coreceptor.
21. Ultra-deep characterization of viral quasispecies in HIV infection
Sammanfattning : HIV-1 has the ability to rapidly diversify and adapt to changes in its environment, such as evading the host immune response, altering cell tropism, and developing resistance to antiretroviral drugs. Minority HIV-1 variants have been shown to be of clinical significance, especially those with non-nucleoside reverse transcriptase inhibitor (NNRTI) drug resistance mutations or determinants of CXCR4 phenotype (X4-virus). LÄS MER
22. Wnt-5a signaling in breast cancer metastasis
Sammanfattning : Breast cancer is the most common form of malignancy affecting women in the Western world. Today, anticancer treatment can control primary breast tumors, but treatment and prevention of metastatic disease still represents a major challenge in the management of breast cancer patients. LÄS MER
23. Wnt/β-Catenin Signalling in Parathyroid Tumours
Sammanfattning : Primary hyperparathyroidism (pHPT) due to parathyroid tumours with hypersecretion of parathyroid hormone and hypercalcaemia is a common disease with incompletely understood etiology affecting more than 1 % of the population, primarily postmenopausal women. In secondary hyperparathyroidism (sHPT), parathyroid tumours develop in response to calcium and vitamin D deficiency generally in patients with uraemia. LÄS MER
24. HIV-1 phenotype and genetic variation in vertical transmission
Sammanfattning : HIV-1 vertical transmission is increasing worldwide despite that successful strategies are available. Reduction of vertical transmission has been established by antiretroviral prophylaxis and elective Caesarian section, but this has been limited to the developed countries. LÄS MER
25. Activation of retrovirus spikes for membrane fusion
Sammanfattning : Retroviruses are enveloped viruses that use reverse transcriptase to convert their RNA genome into DNA which is integrated into the host DNA. They enter into the cell by a membrane fusion process. In this the viral membrane fuses with that of the cell so that the internal capsid of the virus with the genome can be released into the cell cytoplasm. LÄS MER