Sökning: "coreceptor"

Visar resultat 11 - 15 av 35 avhandlingar innehållade ordet coreceptor.

1. 11. Perinatal HIV-1 infection : aspects on clinical presentation, viral dynamics and epidemiology

   Författare :Lars Navér; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Perinatal; HIV-1 infection; disease progression; viral load; genetic subtype; coreceptor; mother-to-child transmission; epidemiology;

   Sammanfattning : During the last 20 years HIV-1 infection has changed from being an unknown disease to being a widespread pandemic, in some areas affecting a large proportion of the human population. Mother-to-child transmission (MTCT) is the predominant route of transmission in children, who thus become infected during a period when their immune system is immature and developing. LÄS MER

3. 12. Significance of HIV-1 genetic subtypes

   Författare :Annette Alaeus; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV-1; genetic subtypes; molecular epidemiology; disease progression; CD4 cell decline; plasma RNA levels; chemokine coreceptor usage;

   Sammanfattning : The human immunodeficiency virus type 1 (HIV-1) displays high genetic variability. Phylogenetic studies have shown that a majority of HIV-1 sequences cluster into one large group called M (major), whereas a few are clearly distinct, group O (outlier) and group N (non-M-non-O). LÄS MER

4. 13. Dynamics of HIV coreceptors and their utilization by plasma and cerebrospinal fluid HIV-1 isolates

   Författare :Ulf Karlsson; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : HIV-1 infection of CD4+ immune cells requires the assistance of cellular coreceptors. The regulation of these receptors is highly dynamic. In addition to the major coreceptors, CCR5 and CXCR4, several alternative coreceptors mediate entry for selected HIV isolates in vitro, although their role in vivo is yet to be established. LÄS MER

5. 14. Biological determinants of HIV infection : studies of viral evolution during disease progression in children and adults

   Författare :Åsa Björndal; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV-1 HIV-2 biological phenotype genetic subtype chemokine receptors disease progression monocyte-derived macrophages;

   Sammanfattning : Coreceptor usage of primary HIV-1 isolates was analysed in relation to their biological phenotype and the severity of HIV-1 infection in the patient. The indicator cell lines, U87 glioma cells engineered to express CD4 and one of the chemokine receptors CCR1, CCR2b, CCR3, CCR5 or CXCR4, were infected with a panel of well-characterized primary HIV-1 isolates. LÄS MER

7. 15. Receptor use of primate lentiviruses

   Författare :Dalma Vödrös; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV; SIV; animal models; receptor use; neutralizing antibodies; CD4-independence;

   Sammanfattning : Human and simian immunodeficiency viruses (HIV and SIV) enter target cells using CD4, the primary cell surface receptor and a secondary receptor, called coreceptor. Coreceptor use of HIV can be related to other biological features of the virus and to the severity of infection as well. LÄS MER