Sökning: "co-receptor use"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden co-receptor use.

  1. 1. HIV-1 patient assessment and treatment : from multitest to co-receptor (CCR5) gene polymorphism : from Rgp160 immunization to highly active antiretroviral treatment (HAART)

    Författare :Göran Bratt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During the last 15 years, understanding of the pathogenesis of HIV- 1 infection and AIDS has developed rapidly. From a mysterious plague-like untreatable disease with unknown cause and transmission route to a well characterized, chronic, manageable, if yet not curable, retroviral infection. LÄS MER

  3. 2. HIV-1 phenotype and genetic variation in vertical transmission

    Författare :Peter Clevestig; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV; co-receptor use; diversity; clade; sequon.;

    Sammanfattning : HIV-1 vertical transmission is increasing worldwide despite that successful strategies are available. Reduction of vertical transmission has been established by antiretroviral prophylaxis and elective Caesarian section, but this has been limited to the developed countries. LÄS MER

  4. 3. The use of peptides for studying molecular events in HIV- and HSV-infections

    Författare :Michael Levi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Synthetic peptides were used as tools in order to study various characteristic sof human immunodeficiency virus (HIV) and herpes simplex virus (HSV). Peptides were designed as multiple antigenic peptides (MAPs) and used as HIV vaccines in experimental animals. The included HIV epitopes were more immunogenic when immunized as MAPs than as a protein. LÄS MER

  5. 4. Molecular characteristics of HIV-1 subtype C and its impact on therapeutic outcome in Ethiopia

    Författare :Amare Worku Kalu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : HIV-1 is characterized by a high genetic diversity which poses several challenges and implications with regard to disease progression, drug resistance and outcome of antiretroviral therapy (ART). HIV-1 subtype C (HIV-1C) is the most rapidly expanding subtype accounting for half of the global disease and nearly all infections in Ethiopia, Southern Africa and India which are the regions with the highest burden of HIV-1 infection. LÄS MER

  7. 5. Translational genomics of HIV-1 subtype C in India : molecular phylogeny and drug resistance

    Författare :Ujjwal Neogi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis describes the translational genomics of HIV-1subtype C in India from its origin to therapeutic response with the aim to improve our knowledge for better therapeutic and preventive strategies to combat HIV/AIDS. In a systemic approach, we identified the molecular phylogeny of HIV-1 subtypes circulating in India and the time to most recent common ancestors (tMRCA) of predominant HIV-1 subtype C strains. LÄS MER